Arl6ip1 - ADP-ribosylation factor-like 6 interacting protein 1 Gene

Mus musculus

Also known as AIP-6; ARMER; Aip-1; Arl6ip; mKIAA0069

Gene ID: 54208 | Gene type: protein coding

About Arl6ip1

Summary

Predicted to enable identical protein binding activity. Involved in positive regulation of L-glutamate import across plasma membrane. Acts upstream of or within cotranslational protein targeting to membrane. Located in cytosol and endoplasmic reticulum. Is integral component of membrane. Part of Sec61 translocon complex. Is expressed in several structures, including central nervous system; genitourinary system; retina; and stomach. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 61. Orthologous to human ARL6IP1 (ADP ribosylation factor like GTPase 6 interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Arl6ip1 Products(1)

mRNA	Protein	Name
NM_019419.2	NP_062292.1	ADP-ribosylation factor-like protein 6-interacting protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10508919	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cotranslational protein targeting to membrane	IDA IDA: Inferred from direct assay	10508919	MGI
involved in positive regulation of L-glutamate import across plasma membrane	IDA IDA: Inferred from direct assay	18684713	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of Sec61 translocon complex	IDA IDA: Inferred from direct assay	10508919	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	10995579	MGI
located in cytosol	IDA IDA: Inferred from direct assay	10508919	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	18684713	MGI
located in intracellular anatomical structure	IDA IDA: Inferred from direct assay	18684713	MGI
located in membrane	IDA IDA: Inferred from direct assay	10995579	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ADP-ribosylation factor-like protein 6-interacting protein 1

ADP-ribosylation-like factor 6 interacting protein

ARL-6-interacting protein 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00994	ARL6IP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21227	Arl6ip1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27744	Arl6ip1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Arl6ip1	NCBI	NCBI:23204

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