2. Gene
  3. Irf6 - interferon regulatory factor 6 Gene

Irf6 - interferon regulatory factor 6 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as mirf6; E230028I05Rik

Gene ID: 54139 | Gene type: protein coding

About Irf6

Summary

Enables DNA binding activity and DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in positive regulation of transcription, DNA-templated. Acts upstream of or within several processes, including epithelial cell differentiation; keratinocyte proliferation; and roof of mouth development. Predicted to be located in cell junction; cytosol; and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; non-neural ectoderm; sensory organ; and skin. Used to study Van der Woude syndrome; cleft lip; and popliteal pterygium syndrome. Human ortholog(s) of this gene implicated in several diseases, including Van der Woude syndrome; cleft lip; orofacial cleft 6; popliteal pterygium syndrome; and syndactyly. Orthologous to human IRF6 (interferon regulatory factor 6). [provided by Alliance of Genome Resources, Apr 2022]

Irf6 Products(1)

mRNA Protein Name
NM_016851.2 NP_058547.2 interferon regulatory factor 6
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables DNA binding IDA
IDA: Inferred from direct assay
19036739 MGI
enables DNA binding IMP
IMP: Inferred from mutant phenotype
19036739 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
19036739 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
19036739 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
28526834 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cell development IMP
IMP: Inferred from mutant phenotype
17041603 MGI
acts upstream of cell population proliferation IGI
IGI: Inferred from genetic interaction
17041603 MGI
acts upstream of or within cranial skeletal system development IMP
IMP: Inferred from mutant phenotype
17041601 MGI
acts upstream of or within keratinocyte differentiation IMP
IMP: Inferred from mutant phenotype
17041601 MGI
acts upstream of keratinocyte proliferation IGI
IGI: Inferred from genetic interaction
17041603 MGI
acts upstream of or within keratinocyte proliferation IGI
IGI: Inferred from genetic interaction
17041603 MGI
acts upstream of or within keratinocyte proliferation IMP
IMP: Inferred from mutant phenotype
17041601 MGI
acts upstream of or within limb development IMP
IMP: Inferred from mutant phenotype
17041601 MGI
involved in mammary gland epithelial cell differentiation IEP
IEP: Inferred from expression pattern
18212048 MGI
acts upstream of or within negative regulation of keratinocyte proliferation IGI
IGI: Inferred from genetic interaction
17041603 MGI
acts upstream of or within negative regulation of stem cell proliferation IGI
IGI: Inferred from genetic interaction
17041603 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
19036739 MGI
acts upstream of or within roof of mouth development IMP
IMP: Inferred from mutant phenotype
21515572 MGI
acts upstream of or within skin development IGI
IGI: Inferred from genetic interaction
17041603 MGI
acts upstream of or within skin development IMP
IMP: Inferred from mutant phenotype
17041601 MGI
acts upstream of stem cell proliferation IGI
IGI: Inferred from genetic interaction
17041603 MGI
acts upstream of or within stem cell proliferation IGI
IGI: Inferred from genetic interaction
17041603 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interferon regulatory factor 6

IRF-6

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06910 IRF6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19906 Irf6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26407 Irf6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Irf6 NCBI NCBI:3664