2. Gene
  3. Map3k14 - mitogen-activated protein kinase kinase kinase 14 Gene

Map3k14 - mitogen-activated protein kinase kinase kinase 14 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Nik; aly

Gene ID: 53859 | Gene type: protein coding

About Map3k14

Summary

Enables NF-kappaB-inducing kinase activity. Involved in I-kappaB kinase/NF-kappaB signaling and immune response. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Is expressed in several structures, including alimentary system; cardiovascular system; nervous system; sensory organ; and skeleton. Used to study Sjogren's syndrome and primary biliary cholangitis. Orthologous to human MAP3K14 (mitogen-activated protein kinase kinase kinase 14). [provided by Alliance of Genome Resources, Apr 2022]

Map3k14 Products(1)

mRNA Protein Name
NM_016896.3 NP_058592.1 mitogen-activated protein kinase kinase kinase 14
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
11239468 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
11239468 MGI
Biological Process GO Annotation Evidence Reference Source
involved in immune response IDA
IDA: Inferred from direct assay
11239468 MGI
involved in non-canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
11239468 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mitogen-activated protein kinase kinase kinase 14

NF kappa B-inducing kinase

NF-kappa-beta-inducing kinase

Nfkb inducing kinase

alymphoplasia

serine/threonine-protein kinase NIK

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08051 MAP3K14 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS20213 Map3k14 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS26718 Map3k14 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Map3k14 NCBI NCBI:9020