2. Gene
  3. Cldn7 - claudin 7 Gene

Cldn7 - claudin 7 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 53624 | Gene type: protein coding

About Cldn7

Summary

This gene encodes a member of the Claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed constitutively in the mammary epithelium throughout development, and might be involved in vesicle trafficking to the basolateral membrane. It is essential for NaCl homeostasis in distal nephrons. The knockout mice lacking this gene showed severe salt wasting, chronic dehydration, and growth retardation, and died within 12 days after birth. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]

Cldn7 Products(2)

mRNA Protein Name
NM_001193619.1 NP_001180548.1 claudin-7 precursor
NM_016887.6 NP_058583.1 claudin-7 precursor
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
10601346 MGI
Cellular Component GO Annotation Evidence Reference Source
located in apicolateral plasma membrane IDA
IDA: Inferred from direct assay
9892664 MGI
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
16651389 MGI
located in bicellular tight junction IDA
IDA: Inferred from direct assay
9892664 MGI
located in lateral plasma membrane IDA
IDA: Inferred from direct assay
22275141 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
16651389 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

claudin-7

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02775 CLDN7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21533 Cldn7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28051 Cldn7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cldn7 NCBI NCBI:1366