Mpp2 - membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) Gene

Mus musculus

Also known as Dlg2; Dlgh2; Pals4; D11Bwg0652e

Gene ID: 50997 | Gene type: protein coding

About Mpp2

Summary

Enables transmembrane transporter binding activity. A structural constituent of postsynaptic density. Involved in excitatory postsynaptic potential and long-term synaptic potentiation. Located in dendrite and glutamatergic synapse. Is anchored component of postsynaptic density membrane. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including central nervous system; genitourinary system; gut gland; respiratory system; and retina. Orthologous to human MPP2 (MAGUK p55 scaffold protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Mpp2 Products(8)

mRNA	Protein	Name
NM_001356324.2	NP_001343253.1	MAGUK p55 subfamily member 2 isoform 1
NM_001414216.1	NP_001401145.1	MAGUK p55 subfamily member 2 isoform 2
NM_001414217.1	NP_001401146.1	MAGUK p55 subfamily member 2 isoform 2
NM_001414218.1	NP_001401147.1	MAGUK p55 subfamily member 2 isoform 2
NM_001414219.1	NP_001401148.1	MAGUK p55 subfamily member 2 isoform 2
NM_001414220.1	NP_001401149.1	MAGUK p55 subfamily member 2 isoform 3
NM_001414221.1	NP_001401150.1	MAGUK p55 subfamily member 2 isoform 4
NM_016695.5	NP_057904.1	MAGUK p55 subfamily member 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12351654	MGI
enables structural constituent of postsynaptic density	IDA IDA: Inferred from direct assay	26880549	MGI
enables structural constituent of postsynaptic density	IEP IEP: Inferred from expression pattern	26880549	MGI
enables structural constituent of postsynaptic density	IMP IMP: Inferred from mutant phenotype	26880549	MGI
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	26880549	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	26880549	MGI
involved in long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	26880549	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	26880549	MGI
is active in Schaffer collateral - CA1 synapse	IEP IEP: Inferred from expression pattern	26880549	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	26880549	MGI
located in dendrite membrane	IDA IDA: Inferred from direct assay	26880549	MGI
located in dendritic shaft	IDA IDA: Inferred from direct assay	26880549	MGI
located in dendritic spine	IDA IDA: Inferred from direct assay	26880549	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	26880549	MGI
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	26880549	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

MAGUK p55 subfamily member 2

discs large homolog 2

p55 subfamily member of MAGUK family

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08623	MPP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19354	Mpp2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25845	Mpp2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mpp2	NCBI	NCBI:4355

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