Olig2 - oligodendrocyte transcription factor 2 Gene

Mus musculus

Also known as RK17; Olg-2; Bhlhb1; Oligo2; bHLHe19

Gene ID: 50913 | Gene type: protein coding

About Olig2

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; HMG box domain binding activity; and identical protein binding activity. Acts upstream of or within negative regulation of neuron differentiation; negative regulation of transcription by RNA polymerase II; and nervous system development. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; epidermis; future brain; genitourinary system; and retina. Orthologous to human OLIG2 (oligodendrocyte transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Olig2 Products(1)

mRNA	Protein	Name
NM_016967.2	NP_058663.2	oligodendrocyte transcription factor 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	14573534	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15655114	MGI
enables HMG box domain binding	IPI IPI: Inferred from physical interaction	16582099	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	15655114	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	14573534	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within myelination	IMP IMP: Inferred from mutant phenotype	16436615	MGI
acts upstream of or within negative regulation of neuron differentiation	IDA IDA: Inferred from direct assay	11566099	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15655114	MGI
acts upstream of or within nervous system development	IDA IDA: Inferred from direct assay	14573534	MGI
acts upstream of neuron differentiation	IDA IDA: Inferred from direct assay	11566099	MGI
acts upstream of or within neuron fate commitment	IMP IMP: Inferred from mutant phenotype	11955448	MGI
acts upstream of oligodendrocyte differentiation	IGI IGI: Inferred from genetic interaction	11566099	MGI
acts upstream of or within oligodendrocyte differentiation	IMP IMP: Inferred from mutant phenotype	16436615	MGI
acts upstream of or within positive regulation of oligodendrocyte differentiation	IGI IGI: Inferred from genetic interaction	11566099	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	14573534	MGI
acts upstream of or within spinal cord motor neuron differentiation	IMP IMP: Inferred from mutant phenotype	21338882	MGI
acts upstream of or within spinal cord oligodendrocyte cell differentiation	IGI IGI: Inferred from genetic interaction	18287202	MGI
acts upstream of or within spinal cord oligodendrocyte cell fate specification	IDA IDA: Inferred from direct assay	18287202	MGI
acts upstream of or within thalamus development	IMP IMP: Inferred from mutant phenotype	19357274	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	14573534	MGI
located in nucleus	IDA IDA: Inferred from direct assay	14573534	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

oligodendrocyte transcription factor 2

Olig2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Olig2	Q9EQW6	Id4	Mus musculus	P41139	Anti Bait CoIP	15280210
Intra	Olig2	Q9EQW6	Id4	Mus musculus	P41139	Confocal	15280210
Intra	Olig2	Q9EQW6	Id4	Mus musculus	P41139	Y2H	15280210
Intra	Olig2	Q9EQW6	Id4	Mus musculus	P41139	Anti Tag CoIP	15280210
Intra	Olig2	Q9EQW6	Id2	Mus musculus	P41136	Anti Bait CoIP	15280210
Intra	Olig2	Q9EQW6	Id2	Mus musculus	P41136	Confocal	15280210
Intra	Olig2	Q9EQW6	Id2	Mus musculus	P41136	Y2H	15280210

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125427	SKOG102	Inhibitor	99.09%	Unkown
HY-175530	OLIG2-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Olig2	NCBI	NCBI:10215

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