Slc7a5 - solute carrier family 7 member 5 Gene

Rattus norvegicus

Also known as E16; TA1; LAT-1

Gene ID: 50719 | Gene type: protein coding

About Slc7a5

Summary

Enables amino acid transmembrane transporter activity. Involved in amino acid import across plasma membrane. Located in basolateral plasma membrane and external side of apical plasma membrane. Orthologous to human SLC7A5 (solute carrier family 7 member 5). [provided by Alliance of Genome Resources, Apr 2022]

Slc7a5 Products(1)

mRNA	Protein	Name
NM_017353.2	NP_059049.1	large neutral amino acids transporter small subunit 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables amino acid transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	28490336	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in L-amino acid transport	IMP IMP: Inferred from mutant phenotype	15980244	RGD
involved in L-leucine transport	IDA IDA: Inferred from direct assay	9726963	RGD
involved in amino acid import across plasma membrane	IMP IMP: Inferred from mutant phenotype	28490336	RGD
involved in cellular response to L-arginine	IEP IEP: Inferred from expression pattern	10681508	RGD
involved in cellular response to amino acid stimulus	IEP IEP: Inferred from expression pattern	9882595	RGD
involved in cellular response to glucose starvation	IEP IEP: Inferred from expression pattern	22185814	RGD
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	29687865	RGD
involved in isoleucine transport	IDA IDA: Inferred from direct assay	11311135	RGD
involved in isoleucine transport	IMP IMP: Inferred from mutant phenotype	25049270	RGD
involved in liver regeneration	IEP IEP: Inferred from expression pattern	9882595	RGD
involved in negative regulation of autophagy	IMP IMP: Inferred from mutant phenotype	25049270	RGD
involved in negative regulation of vascular associated smooth muscle cell apoptotic process	IDA IDA: Inferred from direct assay	29687865	RGD
involved in positive regulation of L-leucine import across plasma membrane	IMP IMP: Inferred from mutant phenotype	25049270	RGD
involved in positive regulation of glial cell proliferation	IMP IMP: Inferred from mutant phenotype	16496379	RGD
involved in response to hyperoxia	IEP IEP: Inferred from expression pattern	25089378	RGD
involved in response to muscle activity	IEP IEP: Inferred from expression pattern	24016666	RGD
involved in tryptophan transport	IDA IDA: Inferred from direct assay	12614332	RGD
involved in valine transport	IMP IMP: Inferred from mutant phenotype	25049270	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	11095508	RGD
located in basal plasma membrane	IDA IDA: Inferred from direct assay	11095508	RGD
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	18619525	RGD
located in external side of apical plasma membrane	IDA IDA: Inferred from direct assay	18619525	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	11311135	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

large neutral amino acids transporter small subunit 1

4F2 LC	4F2 light chain
4F2LC	L-type amino acid transporter 1
TA1/LAT-1/CD98 light chain region	integral membrane protein E16
solute carrier family 7 (amino acid transporter light chain, L system), member 5	solute carrier family 7 (cationic amino ac

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120139	KMH-233	Inhibitor	99.75%	Unkown
HY-RS13331	SLC7A5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17279	Slc7a5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23734	Slc7a5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc7a5	NCBI	NCBI:8140

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