CAPN14 - calpain 14 Gene

Homo sapiens

Gene ID: 440854 | Gene type: protein coding

About CAPN14

Cytogenetic location: 2p23.1 Genomic coordinates (GRCh38): 2:31,173,056-31,233,957 (from NCBI)

This gene has 2 transcripts (splice variants), 301 orthologues and 20 paralogues. Restricted expression toward esophagus (RPKM 73.0).

Summary

Calpains are a family of cytosolic calcium-activated cysteine proteases involved in a variety of cellular processes including Apoptosis, cell division, modulation of integrin-cytoskeletal interactions, and synaptic plasticity (Dear et al., 2000 [PubMed 10964513]). CAPN14 belongs to the calpain large subunit family.[supplied by OMIM, Mar 2008]

CAPN14 Products(2)

mRNA	Protein	Name
NM_001145122.2	NP_001138594.1	calpain-14 isoform 1
NM_001321270.2	NP_001308199.1	calpain-14 isoform 2

CAPN14 Protein Structure

Peptidase_C2

Calpain_III

0
200
400
600
684 a.a.

Protein Preferred Names

Protein Names

calpain-14

CANP 14

Related Diseases

Diseases

Alias

Esophagitis

Acute Esophagitis

Eosinophilic Gastritis

Eosinophilic Enteropathy

Esophagitis, Eosinophilic, 1

Eosinophilic Esophagitis	EOE1
Esophagitis, Eosinophilic	Ee

Esophageal Candidiasis

Candidiasis Of The Esophagus	Candida Esophagitis
Candidal Esophagitis	Esophageal Moniliasis
Esophageal Thrush

Loeys-Dietz Syndrome 2

LDS2	Aat3
Marfan Syndrome Type 2	Aortic Aneurysm, Familial Thoracic 3
Marfan Syndrome Type Ii	Loeys-Dietz Syndrome Type 2
Mfs2	Marfan Syndrome, Type Ii, Formerly
Familial Throacic Aortic Aneurysm 3	Familial Aortic Aneurysm Thoracic Type 3
Taad2	Thoracic Aortic Aneurysms And Dissection 2
Aneurysm, Aortic, Thoracic, Familial, Type 3	Loeys-Dietz Syndrome, Type 2

Dyskinesia Of Esophagus

Esophageal Motility Disorders	Dyskinesia Of Oesophagus
Esophageal Dysmotility	Esophageal Motility Disorder
Oesophageal Dysmotility	Oesophageal Motor Disorder
Esophageal Spasm

Hypermobility Syndrome

Benign Joint Hypermobility

Pinguecula

Conjunctival Degeneration

Loeys-Dietz Syndrome

Loeys-Dietz Aortic Aneurysm Syndrome	Lds
Aortic Aneurysm Syndrome Due To Tgf-Beta Receptors Anomalies	Furlong Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01887	CAPN14 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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