PRSS57 - serine protease 57 Gene

Homo sapiens

Also known as NSP4; PRSSL1; UNQ782

Gene ID: 400668 | Gene type: protein coding

About PRSS57

This gene has 2 transcripts (splice variants), 114 orthologues and 14 paralogues. Restricted expression toward bone marrow (RPKM 54.0).

Summary

This gene encodes an arginine-specific serine protease and member of the peptidase S1 family of proteins. The encoded protein may undergo proteolytic activation before storage in azurophil granules, in neutrophil cells of the immune system. Following neutrophil activation, the protease is released into the pericellular environment, where it may play a role in defense against microbial pathogens. [provided by RefSeq, Jul 2016]

PRSS57 Products(2)

mRNA	Protein	Name
NM_001308209.2	NP_001295138.2	serine protease 57 isoform 2 precursor
NM_214710.5	NP_999875.2	serine protease 57 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables heparin binding	IDA IDA: Inferred from direct assay	25156428	GOA
enables serine-type peptidase activity	IDA IDA: Inferred from direct assay	25156428	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in proteolysis	IDA IDA: Inferred from direct assay	22474388	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in azurophil granule lumen	IDA IDA: Inferred from direct assay	23904161	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	22474388	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRSS57 Protein Structure

Trypsin

0
100
200
283 a.a.

Protein Preferred Names

Protein Names

serine protease 57

neutrophil serine protease 4

Related Diseases

Diseases

Alias

Eastern Equine Encephalitis

Eee	Neuroinvasive Eastern Equine Encephalitis Virus Infection
Eastern Equine Encephalomyelitis	Encephalomyelitis, Eastern Equine
Triple E	Eastern Equine Encephalitis Virus Infection
Neuroinvasive Eastern Equine Encephalitis Virus Disease	Eee - [Eastern Equine Encephalitis]

Western Equine Encephalitis

Western Equine Encephalomyelitis	Wee
Encephalomyelitis, Western Equine	Western Equine Encephalitis Virus Infection
Wee - [Western Equine Encephalitis]	Western Equine Encephalitis Virus

Osmotic Diarrhea

Acute Diarrhea

Secretory Diarrhea

Venezuelan Equine Encephalitis

Venezuelan Equine Fever	Venezuelan Equine Encephalomyelitis
Encephalitis Venezuelan Equine	Encephalomyelitis, Venezuelan Equine
Venezuelan Encephalitis	Disorder Due To Venezuelan Equine Encephalitis Virus
Venezuelan Equine Encephalitis Virus Infection	Venezuelan Equine Encephalomyelitis Virus Disease

Papillon-Lefevre Syndrome

Papillon-Lefevre Disease	Papillon-Lefèvre Syndrome
PLS	Keratosis Palmoplantaris With Periodontopathia
PALS	Papillon Lefevre Syndrome
Keratosis Palmoplantar-Periodontopathy Syndrome	Papillon-Lefvre Syndrome
Hyperkeratosis Palmoplantaris With Periodontosis	Keratoris Palmoplantaris With Periodontopathia
Keratosis Palmoplantar - Periodontopathy	Palmar-Plantar Hyperkeratosis And Concomitant Periodontal Destruction
Palmoplantar Keratoderma With Periodontosis	Palsy

Noonan Syndrome 4

NS4	Noonan Syndrome, Type 4

Griscelli Syndrome, Type 3

Griscelli Syndrome Type 3	GS3
Griscelli-Prunieras Syndrome Type 3	Hypomelanosis With No Immunologic Or Neurologic Manifestations
Griscelli Syndrome 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11258	PRSS57 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21915	Prss57 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PRSS57	VGNC	VGNC:64403
Bos taurus	PRSS57	VGNC	VGNC:33425
Macaca mulatta	PRSS57	VGNC	VGNC:76352
Rattus norvegicus	PRSS57	RGD	RGD:1303330
Canis familiaris	PRSS57	VGNC	VGNC:54343
Mus musculus	PRSS57	MGD	MGI:1920356

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