2. Gene
  3. Fbxo7 - F-box protein 7 Gene

Fbxo7 - F-box protein 7 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 366854 | Gene type: protein coding

About Fbxo7

Summary

Predicted to enable several functions, including enzyme binding activity; protein heterodimerization activity; and ubiquitin ligase-substrate adaptor activity. Involved in negative regulation of neuron death and positive regulation of Autophagy of mitochondrion. Predicted to be located in several cellular components, including Lewy body core; Lewy body corona; and Lewy neurite. Predicted to be part of SCF ubiquitin Ligase complex. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 15. Orthologous to human FBXO7 (F-box protein 7). [provided by Alliance of Genome Resources, Apr 2022]

Fbxo7 Products(1)

mRNA Protein Name
NM_001012222.1 NP_001012222.1 F-box only protein 7
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
acts upstream of negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
26310625 RGD
involved in positive regulation of mitophagy IMP
IMP: Inferred from mutant phenotype
26310625 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

F-box only protein 7

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04813 FBXO7 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS22503 Fbxo7 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS29025 Fbxo7 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fbxo7 NCBI NCBI:25793