Irf6 - interferon regulatory factor 6 Gene

About Irf6

Summary

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in immune system process; positive regulation of transcription by RNA polymerase II; and regulation of cell cycle. Predicted to act upstream of or within several processes, including epithelial cell differentiation; keratinocyte proliferation; and roof of mouth development. Predicted to be located in cell junction; cytosol; and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in several diseases, including Van der Woude syndrome; cleft lip; orofacial cleft 6; popliteal pterygium syndrome; and syndactyly. Orthologous to human IRF6 (interferon regulatory factor 6). [provided by Alliance of Genome Resources, Apr 2022]