MAP2K7 - Map2k7 mitogen activated protein kinase kinase 7 Gene

Rattus norvegicus

Also known as JNKK; Mek7; Mkk7; Jnkk2; Mapkk7

Gene ID: 363855 | Gene type: protein coding

About MAP2K7

Summary

Enables several functions, including ATP binding activity; JUN kinase kinase activity; and magnesium ion binding activity. Involved in several processes, including JNK cascade; cellular response to sorbitol; and positive regulation of JNK cascade. Located in cytosol and nucleus. Orthologous to human MAP2K7 (mitogen-activated protein kinase kinase 7). [provided by Alliance of Genome Resources, Apr 2022]

MAP2K7 Products(2)

mRNA	Protein	Name
NM_001025425.2	NP_001020596.1	dual specificity mitogen-activated protein kinase kinase 7 isoform 1
NM_001401207.1	NP_001388136.1	dual specificity mitogen-activated protein kinase kinase 7 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	10051439	RGD
enables JUN kinase kinase activity	IDA IDA: Inferred from direct assay	10051439	RGD
enables MAP kinase kinase activity	IDA IDA: Inferred from direct assay	10051439	RGD
enables magnesium ion binding	IDA IDA: Inferred from direct assay	10051439	RGD
enables mitogen-activated protein kinase kinase kinase binding	IPI IPI: Inferred from physical interaction	14575811	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15816852	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in JNK cascade	IDA IDA: Inferred from direct assay	10051439	RGD
involved in cellular response to osmotic stress	IDA IDA: Inferred from direct assay	10051439	RGD
involved in cellular response to sorbitol	IEP IEP: Inferred from expression pattern	20550965	RGD
involved in positive regulation of JNK cascade	IDA IDA: Inferred from direct assay	10051439	RGD
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	12514131	RGD
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	20550965	RGD
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	10051439	RGD
involved in response to osmotic stress	IDA IDA: Inferred from direct assay	10051439	RGD
involved in stress-activated MAPK cascade	IDA IDA: Inferred from direct assay	10051439	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

dual specificity mitogen-activated protein kinase kinase 7

JNK kinase 2	JNK-activating kinase 2
JNKK 2	MAP kinase kinase 7
MAPK/ERK kinase 7	MAPKK 7
MEK 7	c-Jun N-terminal kinase kinase 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-171178	DK2403		/	Unkown
HY-RS08045	MAP2K7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-D2415	BODIPY-FL staurosporine		/	Unkown
HY-RS19790	Map2k7 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26286	Map2k7 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	MAP2K7	NCBI	NCBI:5609

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