2. Gene
  3. Spg7 - SPG7 matrix AAA peptidase subunit, paraplegin Gene

Spg7 - SPG7 matrix AAA peptidase subunit, paraplegin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 353231 | Gene type: protein coding

About Spg7

Summary

Predicted to enable ATP binding activity; peptidase activity; and zinc ion binding activity. Involved in mitochondrial outer membrane permeabilization involved in programmed cell death. Predicted to be located in mitochondrial inner membrane. Predicted to be part of m-AAA complex. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 7. Orthologous to human SPG7 (SPG7 matrix AAA peptidase subunit, paraplegin). [provided by Alliance of Genome Resources, Apr 2022]

Spg7 Products(2)

mRNA Protein Name
NM_001399110.1 NP_001386039.1 paraplegin isoform 2
NM_181388.3 NP_852053.1 paraplegin isoform 1
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in mitochondrial outer membrane permeabilization involved in programmed cell death IMP
IMP: Inferred from mutant phenotype
26387735 RGD
involved in regulation of mitochondrial membrane permeability IMP
IMP: Inferred from mutant phenotype
26387735 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

paraplegin

SPG7, paraplegin matrix AAA peptidase subunit

spastic paraplegia 7 homolog

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13663 SPG7 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS21436 Spg7 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS27954 Spg7 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Spg7 NCBI NCBI:6687