2. Gene
  3. SMTNL2 - smoothelin like 2 Gene

SMTNL2 - smoothelin like 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 342527 | Gene type: protein coding

About SMTNL2

This gene has 4 transcripts (splice variants), 256 orthologues and 36 paralogues. Biased expression in kidney (RPKM 11.1), prostate (RPKM 2.3) and 8 other tissues.

Summary

Predicted to enable protein Phosphatase 1 binding activity and tropomyosin binding activity. Predicted to be involved in actin Cytoskeleton organization and positive regulation of vasoconstriction. Predicted to be part of filamentous actin. Predicted to be active in I band; M band; and microtubule organizing center. [provided by Alliance of Genome Resources, Apr 2022]

SMTNL2 Products(3)

mRNA Protein Name
NM_001114974.2 NP_001108446.1 smoothelin-like protein 2 isoform 1
NM_001375361.1 NP_001362290.1 smoothelin-like protein 2 isoform 3
NM_198501.3 NP_940903.2 smoothelin-like protein 2 isoform 2

SMTNL2 Protein Structure

CH

CH: Calponin homology (CH) domain (355 - 457)

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  • 461 a.a.
Protein Preferred Names Protein Names

smoothelin-like protein 2

Related Diseases

Diseases Alias
Cerebrovascular Benign Neoplasm
Leukodystrophy, Hypomyelinating, 2

Pmld1

Hypomyelinating Leukodystrophy 2

HLD2

Pelizaeus-Merzbacher-Like Disease 1

Pelizaeus-Merzbacher-Like Disease Due To Gjc2 Mutation

Pelizaeus-Merzbacher-Like Disease Type 1

Pelizaeus-Merzbacher-Like Disease, 1

Pelizaeus Merzbacher Like Disease

Pelizaeus-Merzbacher-Like Disease

Pmld - Pelizaeus Merzbacher Like Disease

Pelizaeus-Merzbacher-Like Disease Autosomal Recessive Type 1

Pmldar1

Leukodystrophy, Hypomyelinating, Type 2
Papilloma Of Choroid Plexus

Choroid Plexus Papilloma

CPP

Childhood Choroid Plexus Papilloma

Papilloma Choroid Plexus

Papilloma, Choroid Plexus

Choroid Plexus Carcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13456 SMTNL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SMTNL2 VGNC VGNC:77770
Rattus norvegicus SMTNL2 RGD RGD:1585960
Canis familiaris SMTNL2 VGNC VGNC:46577
Mus musculus SMTNL2 MGD MGI:2442764
Bos taurus SMTNL2 VGNC VGNC:35037
Felis catus SMTNL2 VGNC VGNC:65508