2. Gene
  3. Chd7 - chromodomain helicase DNA binding protein 7 Gene

Chd7 - chromodomain helicase DNA binding protein 7 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Dz; Mt; Cyn; Edy; Flo; Lda; Obt; Whi; Cycn; Todo; WBE1; metis; GENA 47; GENA 60; Gena 52; A730019I05Rik

Gene ID: 320790 | Gene type: protein coding

About Chd7

Summary

This gene encodes a protein containing two chromodomains and an ATP-binding helicase domain that functions as a regulator of transcription. Mutations in this gene result in an array of development defects, including inner ear problems. Mice defective for this gene exhibit many of the clinical features of the CHARGE syndrome caused by mutations in the homologous gene in human. [provided by RefSeq, Sep 2015]

Chd7 Products(2)

mRNA Protein Name
NM_001277149.1 NP_001264078.1 chromodomain-helicase-DNA-binding protein 7 isoform 1
NM_001355382.1 NP_001342311.1 chromodomain-helicase-DNA-binding protein 7 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
23319608 MGI
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
26102480 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
21532573 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within adult heart development IMP
IMP: Inferred from mutant phenotype
16207732 MGI
acts upstream of or within adult walking behavior IMP
IMP: Inferred from mutant phenotype
16207732 MGI
acts upstream of or within aorta development IMP
IMP: Inferred from mutant phenotype
26102480 MGI
acts upstream of or within aorta morphogenesis IMP
IMP: Inferred from mutant phenotype
26102480 MGI
acts upstream of or within artery morphogenesis IGI
IGI: Inferred from genetic interaction
19855134 MGI
acts upstream of or within atrioventricular canal development IMP
IMP: Inferred from mutant phenotype
26102480 MGI
acts upstream of or within blood circulation IMP
IMP: Inferred from mutant phenotype
16207732 MGI
acts upstream of or within blood vessel development IMP
IMP: Inferred from mutant phenotype
16207732 MGI
acts upstream of or within blood vessel remodeling IMP
IMP: Inferred from mutant phenotype
26102480 MGI
acts upstream of or within camera-type eye development IMP
IMP: Inferred from mutant phenotype
16207732 MGI
acts upstream of or within cardiac septum morphogenesis IMP
IMP: Inferred from mutant phenotype
26102480 MGI
acts upstream of or within chromatin remodeling IMP
IMP: Inferred from mutant phenotype
26102480 MGI
acts upstream of or within ear morphogenesis IMP
IMP: Inferred from mutant phenotype
10932191 MGI
acts upstream of or within embryonic hindlimb morphogenesis IMP
IMP: Inferred from mutant phenotype
16207732 MGI
acts upstream of or within epithelium development IMP
IMP: Inferred from mutant phenotype
19279158 MGI
acts upstream of or within female genitalia development IMP
IMP: Inferred from mutant phenotype
16207732 MGI
acts upstream of or within heart morphogenesis IMP
IMP: Inferred from mutant phenotype
16207732 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
16207732 MGI
acts upstream of or within inner ear morphogenesis IMP
IMP: Inferred from mutant phenotype
15353999 MGI
acts upstream of or within innervation IMP
IMP: Inferred from mutant phenotype
26102480 MGI
acts upstream of or within locomotory behavior IMP
IMP: Inferred from mutant phenotype
10932191 MGI
acts upstream of or within nose development IMP
IMP: Inferred from mutant phenotype
16207732 MGI
acts upstream of or within olfactory behavior IMP
IMP: Inferred from mutant phenotype
19279158 MGI
acts upstream of or within olfactory bulb development IMP
IMP: Inferred from mutant phenotype
19279158 MGI
acts upstream of or within olfactory nerve development IMP
IMP: Inferred from mutant phenotype
19279158 MGI
acts upstream of or within positive regulation of multicellular organism growth IMP
IMP: Inferred from mutant phenotype
16207732 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
26102480 MGI
acts upstream of or within regulation of neurogenesis IMP
IMP: Inferred from mutant phenotype
19279158 MGI
acts upstream of or within regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IMP
IMP: Inferred from mutant phenotype
26102480 MGI
acts upstream of or within response to bacterium IEP
IEP: Inferred from expression pattern
23012479 MGI
acts upstream of or within right ventricular compact myocardium morphogenesis IMP
IMP: Inferred from mutant phenotype
26102480 MGI
acts upstream of or within roof of mouth development IMP
IMP: Inferred from mutant phenotype
16207732 MGI
acts upstream of or within semicircular canal morphogenesis IGI
IGI: Inferred from genetic interaction
19855134 MGI
acts upstream of or within sensory perception of sound IMP
IMP: Inferred from mutant phenotype
10932191 MGI
acts upstream of or within tissue remodeling IMP
IMP: Inferred from mutant phenotype
26102480 MGI
acts upstream of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
26102480 MGI
acts upstream of or within ventricular trabecula myocardium morphogenesis IMP
IMP: Inferred from mutant phenotype
26102480 MGI
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
26102480 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

chromodomain-helicase-DNA-binding protein 7

ATP-dependent helicase CHD7

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-111303 CHIC35 Inhibitor / Unkown
HY-RS02612 CHD7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17534 Chd7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21310 Chd3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23991 Chd7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Chd7 NCBI NCBI:55636