2. Gene
  3. Auts2 - autism susceptibility candidate 2 Gene

Auts2 - autism susceptibility candidate 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as 2700063G02Rik; A730011F23Rik; D830032G16Rik

Gene ID: 319974 | Gene type: protein coding

About Auts2

Summary

Predicted to enable chromatin binding activity. Involved in several processes, including generation of neurons; positive regulation of Rac protein signal transduction; and positive regulation of lamellipodium assembly. Acts upstream of or within innate vocalization behavior and righting reflex. Located in growth cone and nucleus. Colocalizes with actin Cytoskeleton. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study autosomal dominant non-syndromic intellectual disability and autosomal dominant non-syndromic intellectual disability 26. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 26. Orthologous to human AUTS2 (activator of transcription and developmental regulator AUTS2). [provided by Alliance of Genome Resources, Apr 2022]

Auts2 Products(1)

mRNA Protein Name
NM_001363480.1 NP_001350409.1 autism susceptibility gene 2 protein homolog
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25519132 MGI
Biological Process GO Annotation Evidence Reference Source
involved in actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
25533347 MGI
involved in axon extension IMP
IMP: Inferred from mutant phenotype
25533347 MGI
involved in dendrite extension IMP
IMP: Inferred from mutant phenotype
25533347 MGI
acts upstream of or within innate vocalization behavior IMP
IMP: Inferred from mutant phenotype
25519132 MGI
involved in neuron migration IMP
IMP: Inferred from mutant phenotype
25533347 MGI
involved in positive regulation of Rac protein signal transduction IMP
IMP: Inferred from mutant phenotype
25533347 MGI
involved in positive regulation of lamellipodium assembly IMP
IMP: Inferred from mutant phenotype
25533347 MGI
acts upstream of or within righting reflex IMP
IMP: Inferred from mutant phenotype
25519132 MGI
Cellular Component GO Annotation Evidence Reference Source
colocalizes with actin cytoskeleton IDA
IDA: Inferred from direct assay
25533347 MGI
located in growth cone IDA
IDA: Inferred from direct assay
25533347 MGI
located in nucleus IDA
IDA: Inferred from direct assay
19948250 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

autism susceptibility gene 2 protein homolog

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01276 AUTS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21493 Auts2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28011 Auts2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Auts2 NCBI NCBI:26053