2. Gene
  3. Ercc6 - excision repair cross-complementing rodent repair deficiency, complementation group 6 Gene

Ercc6 - excision repair cross-complementing rodent repair deficiency, complementation group 6 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as CSB; 4732403I04; C130058G22Rik

Gene ID: 319955 | Gene type: protein coding

About Ercc6

Summary

Predicted to enable several functions, including ATP binding activity; protein C-terminus binding activity; and protein tyrosine kinase activator activity. Acts upstream of or within several processes, including intracellular signal transduction; nucleic acid metabolic process; and photoreceptor cell maintenance. Predicted to be located in nuclear body; nucleolus; and site of DNA damage. Predicted to be part of transcription elongation factor complex. Predicted to be active in nucleus. Is expressed in genitourinary system. Used to study Cockayne syndrome. Human ortholog(s) of this gene implicated in several diseases, including Cockayne syndrome (multiple); De Sanctis-Cacchione syndrome; UV-sensitive syndrome; age related macular degeneration 5; and primary ovarian insufficiency 11. Orthologous to human ERCC6 (ERCC excision repair 6, chromatin remodeling factor). [provided by Alliance of Genome Resources, Apr 2022]

Ercc6 Products(1)

mRNA Protein Name
NM_001081221.2 NP_001074690.1 DNA excision repair protein ERCC-6
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within DNA damage response IMP
IMP: Inferred from mutant phenotype
11408355 MGI
acts upstream of or within DNA repair IGI
IGI: Inferred from genetic interaction
12447686 MGI
acts upstream of or within DNA repair IMP
IMP: Inferred from mutant phenotype
10806208 MGI
acts upstream of or within JNK cascade IMP
IMP: Inferred from mutant phenotype
16319174 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IMP
IMP: Inferred from mutant phenotype
11005836 MGI
acts upstream of or within multicellular organism growth IGI
IGI: Inferred from genetic interaction
22323595 MGI
acts upstream of or within photoreceptor cell maintenance IMP
IMP: Inferred from mutant phenotype
17145777 MGI
acts upstream of or within positive regulation of transcription initiation by RNA polymerase II IGI
IGI: Inferred from genetic interaction
22323595 MGI
acts upstream of or within positive regulation of transcription initiation by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
22323595 MGI
acts upstream of or within pyrimidine dimer repair IMP
IMP: Inferred from mutant phenotype
9150142 MGI
acts upstream of or within response to UV IMP
IMP: Inferred from mutant phenotype
10843671 MGI
acts upstream of or within response to UV-B IMP
IMP: Inferred from mutant phenotype
10850428 MGI
acts upstream of or within response to X-ray IMP
IMP: Inferred from mutant phenotype
15979950 MGI
acts upstream of or within response to gamma radiation IMP
IMP: Inferred from mutant phenotype
15340056 MGI
acts upstream of or within response to oxidative stress IMP
IMP: Inferred from mutant phenotype
12509265 MGI
acts upstream of or within response to superoxide IMP
IMP: Inferred from mutant phenotype
15340056 MGI
acts upstream of or within response to toxic substance IMP
IMP: Inferred from mutant phenotype
11408355 MGI
acts upstream of or within transcription elongation by RNA polymerase I IMP
IMP: Inferred from mutant phenotype
23562818 MGI
acts upstream of or within transcription-coupled nucleotide-excision repair IMP
IMP: Inferred from mutant phenotype
9150142 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA excision repair protein ERCC-6

ATP-dependent helicase ERCC6

CS group B correcting

cockayne syndrome protein CSB

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04483 ERCC6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04484 ERCC6L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04485 ERCC6L2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20400 Ercc6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21852 Ercc6l Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26909 Ercc6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28369 Ercc6l Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ercc6 NCBI NCBI:2074