Atf1 - activating transcription factor 1 Gene

Rattus norvegicus

Also known as Atf-1

Gene ID: 315305 | Gene type: protein coding

About Atf1

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in several processes, including positive regulation of macromolecule biosynthetic process; positive regulation of neuron projection development; and response to cobalt ion. Located in nucleus. Part of transcription regulator complex. Biomarker of polycystic kidney disease. Orthologous to human ATF1 (activating transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Atf1 Products(1)

mRNA	Protein	Name
NM_001100895.1	NP_001094365.1	cyclic AMP-dependent transcription factor ATF-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	14576830	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	16373341	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	9489722	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15084519	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of DNA replication	IMP IMP: Inferred from mutant phenotype	11925444	RGD
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	9489722	RGD
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17822438	RGD
involved in protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	10770487	RGD
involved in response to cobalt ion	IEP IEP: Inferred from expression pattern	10559391	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	10683356	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of transcription regulator complex	IDA IDA: Inferred from direct assay	14576830	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cyclic AMP-dependent transcription factor ATF-1

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-103100	SB-699551		99.53%	Unkown
HY-108618	BC11-38	Inhibitor	99.42%	Unkown
HY-N12887	Mycothiazole	Inhibitor	/	Unkown
HY-RS01127	ATF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05361	GDNF Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18337	Atf1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24816	Atf1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Atf1	NCBI	NCBI:466

Name
Email *

	Sorry, but the email address you supplied was invalid.