2. Gene
  3. Mrtfa - myocardin related transcription factor A Gene

Mrtfa - myocardin related transcription factor A Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as BSAC; Mkl1; FLMKL1; MELODY; Mrtf-a; MKL1met

Gene ID: 315151 | Gene type: protein coding

About Mrtfa

Summary

Predicted to enable several functions, including actin monomer binding activity; leucine zipper domain binding activity; and transcription coactivator activity. Involved in regulation of transcription by RNA polymerase II. Located in nucleus. Human ortholog(s) of this gene implicated in acute megakaryocytic leukemia and immunodeficiency 66. Orthologous to human MRTFA (myocardin related transcription factor A). [provided by Alliance of Genome Resources, Apr 2022]

Mrtfa Products(1)

mRNA Protein Name
NM_001401049.1 NP_001387978.1 MKL/myocardin-like protein 1
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in regulation of modification of postsynaptic structure IDA
IDA: Inferred from direct assay
29335431 RGD
involved in regulation of modification of postsynaptic structure IMP
IMP: Inferred from mutant phenotype
29335431 RGD
involved in regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17005865 RGD
Cellular Component GO Annotation Evidence Reference Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
29335431 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
29335431 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
29335431 RGD
is active in presynapse IDA
IDA: Inferred from direct assay
29335431 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

MKL/myocardin-like protein 1

myocardin-related transcription factor A

MKL1-elongated derivative of yield protein

basic, SAP, and coiled-coil domain containing protein

megakaryoblastic leukemia (translocation) 1

megakaryoblastic leukemia 1 met

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-120855 CCG-100602 Inhibitor 99.29% Unkown
HY-13991A (S)-CCG-1423 / Unkown
HY-162968 MRTF-A-IN-1 Inhibitor / Unkown
HY-162969 MRTF-A-IN-2 Inhibitor / Unkown
HY-RS08693 MRTFA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS21655 Mrtfa Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS28173 Mrtfa Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mrtfa NCBI NCBI:57591