1. Gene
  2. Fos - Fos proto-oncogene, AP-1 transcription factor subunit Gene

Fos - Fos proto-oncogene, AP-1 transcription factor subunit Gene

Rattus norvegicus

Also known as c-fos

Gene ID: 314322 | Gene type: protein coding

About Fos

Summary

Enables DNA-binding transcription factor activity; double-stranded DNA binding activity; and sequence-specific DNA binding activity. Involved in several processes, including conditioned taste aversion; positive regulation of pri-miRNA transcription by RNA polymerase II; and response to steroid hormone. Located in membrane; neuron projection; and nucleus. Biomarker of congestive heart failure; glomerulonephritis; and hypertension. Orthologous to human FOS (Fos proto-oncogene, AP-1 transcription factor subunit). [provided by Alliance of Genome Resources, Apr 2022]

Fos Products(1)

mRNA Protein Name
NM_022197.2 NP_071533.1 protein c-Fos
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA binding IDA
IDA: Inferred from direct assay
2105492 RGD
enables DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
10830307 RGD
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
2105492 RGD
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
29330744 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
7665092 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
2105492 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
9369238 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
10830307 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to epidermal growth factor stimulus IEP
IEP: Inferred from expression pattern
8603605 RGD
involved in cellular response to hormone stimulus IEP
IEP: Inferred from expression pattern
11460264 RGD
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
8593588 RGD
involved in cellular response to parathyroid hormone stimulus IEP
IEP: Inferred from expression pattern
8603605 RGD
involved in cellular response to phorbol 13-acetate 12-myristate IEP
IEP: Inferred from expression pattern
8603605 RGD
involved in cellular response to prolactin IEP
IEP: Inferred from expression pattern
8584023 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: Inferred from expression pattern
23110133 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
23110133 RGD
involved in cellular response to zinc ion starvation IEP
IEP: Inferred from expression pattern
21893222 RGD
involved in cerebral cortex development IMP
IMP: Inferred from mutant phenotype
32385110 RGD
involved in conditioned taste aversion IEP
IEP: Inferred from expression pattern
18374904 RGD
involved in female pregnancy IEP
IEP: Inferred from expression pattern
12080023 RGD
involved in medium-term memory IMP
IMP: Inferred from mutant phenotype
22532480 RGD
involved in mononuclear cell differentiation IEP
IEP: Inferred from expression pattern
23110133 RGD
involved in myoblast proliferation IEP
IEP: Inferred from expression pattern
2425941 RGD
involved in neural retina development IEP
IEP: Inferred from expression pattern
20589906 RGD
involved in neuron differentiation IMP
IMP: Inferred from mutant phenotype
32385110 RGD
involved in positive regulation of miRNA transcription IDA
IDA: Inferred from direct assay
18384814 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
24286756 RGD
involved in response to cAMP IEP
IEP: Inferred from expression pattern
18280640 RGD
involved in response to corticosterone IEP
IEP: Inferred from expression pattern
18485334 RGD
involved in response to cytokine IEP
IEP: Inferred from expression pattern
18280640 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
22576626 RGD
involved in response to gravity IEP
IEP: Inferred from expression pattern
17274184 RGD
involved in response to immobilization stress IEP
IEP: Inferred from expression pattern
17936518 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
20818503 RGD
involved in response to light stimulus IEP
IEP: Inferred from expression pattern
11146118 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
11389931 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
15126239 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
10934195 RGD
involved in response to progesterone IEP
IEP: Inferred from expression pattern
12080023 RGD
involved in response to steroid hormone IEP
IEP: Inferred from expression pattern
21948387 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
11295234 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
12243769 RGD
involved in skeletal muscle cell proliferation IEP
IEP: Inferred from expression pattern
2447874 RGD
involved in transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
10830307 RGD
Cellular Component GO Annotation Evidence Reference Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
32385110 RGD
located in nuclear matrix IDA
IDA: Inferred from direct assay
20053986 RGD
located in nucleoplasm IDA
IDA: Inferred from direct assay
20053986 RGD
located in nucleus IDA
IDA: Inferred from direct assay
7595148 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein c-Fos

FBJ murine osteosarcoma viral oncogene homolog

FBJ osteosarcoma oncogene

c-fos oncogene

proto-oncogene c-FOS

proto-oncogene cFOS

v-fos FBJ murine osteosarcoma viral oncogene homolog

Orthologs Information

Species Symbol Source ID
Homo sapiens Fos NCBI NCBI:2353
Macaca fascicularis Fos NCBI NCBI:102143716