2. Gene
  3. Hjv - hemojuvelin BMP co-receptor Gene

Hjv - hemojuvelin BMP co-receptor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Hfe2; Rgmc

Gene ID: 310681 | Gene type: protein coding

About Hjv

Summary

Predicted to enable BMP binding activity; coreceptor activity; and Transferrin Receptor binding activity. Predicted to contribute to BMP Receptor activity. Predicted to be involved in several processes, including cellular iron ion homeostasis; protein autoprocessing; and transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to act upstream of or within iron ion homeostasis; negative regulation of BMP signaling pathway; and positive regulation of transcription by RNA polymerase II. Located in basolateral plasma membrane. Human ortholog(s) of this gene implicated in hemochromatosis and hemochromatosis type 2A. Orthologous to human HJV (hemojuvelin BMP co-receptor). [provided by Alliance of Genome Resources, Apr 2022]

Hjv Products(1)

mRNA Protein Name
NM_001012080.2 NP_001012080.1 hemojuvelin precursor
Gene Ontology
  • Cellular Component
Cellular Component GO Annotation Evidence Reference Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
16932966 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hemojuvelin

RGM domain family member C

hemochromatosis type 2 (juvenile) (human homolog)

hemochromatosis type 2 protein homolog

hemojuvelin BMP coreceptor

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-176305S Neurofilament, U-15N / Unkown
HY-RS06191 HJV Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18590 Hjv Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25075 Hjv Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hjv NCBI NCBI:148738
Macaca fascicularis Hjv NCBI NCBI:102138915
Mus musculus Hjv NCBI NCBI:69585