2. Gene
  3. Trio - trio Rho guanine nucleotide exchange factor Gene

Trio - trio Rho guanine nucleotide exchange factor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 310192 | Gene type: protein coding

About Trio

Summary

Enables enzyme binding activity. Predicted to be involved in axon guidance and negative regulation of fat cell differentiation. Predicted to be located in cell projection. Predicted to be active in cytoplasm. Predicted to be extrinsic component of membrane. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability and autosomal dominant non-syndromic intellectual disability 44. Orthologous to human TRIO (trio Rho guanine nucleotide exchange factor). [provided by Alliance of Genome Resources, Apr 2022]

Trio Products(1)

mRNA Protein Name
NM_001107658.3 NP_001101128.3 triple functional domain protein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
15331630 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
31801062 RGD
Biological Process GO Annotation Evidence Reference Source
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
26858404 RGD
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
26858404 RGD
Cellular Component GO Annotation Evidence Reference Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
26858404 RGD
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
26858404 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
27907191 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
27907191 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
27907191 RGD
is active in postsynapse IMP
IMP: Inferred from mutant phenotype
27907191 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

triple functional domain protein

PTPRF-interacting protein

triple functional domain (PTPRF interacting)

Trio Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Trio F1M0Z1 Nlgn1 Rattus norvegicus Q62765
Anti Bait CoIP
31801062
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16663 ITX3 Inhibitor 98.60% Unkown
HY-N1783 (24E)-3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid Inhibitor / Unkown
HY-RS15074 TRIO Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS17820 Trio Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24288 Trio Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Trio NCBI NCBI:7204
Macaca fascicularis Trio NCBI NCBI:102115266
Mus musculus Trio NCBI NCBI:223435
Macaca mulatta Trio NCBI NCBI:717492