MFF - Mff mitochondrial fission factor Gene

Rattus norvegicus

Also known as RGD1310230

Gene ID: 301563 | Gene type: protein coding

About MFF

Summary

Enables GTPase binding activity. Involved in several processes, including cellular response to hydrogen peroxide; positive regulation of cardiac muscle cell apoptotic process; and positive regulation of cellular component organization. Located in synaptic vesicle. Colocalizes with mitochondrial membrane and synaptic vesicle membrane. Used to study transient cerebral ischemia. Orthologous to human MFF (mitochondrial fission factor). [provided by Alliance of Genome Resources, Apr 2022]

MFF Products(3)

mRNA	Protein	Name
NM_001039015.2	NP_001034104.1	mitochondrial fission factor isoform 2
NM_001271284.1	NP_001258213.1	mitochondrial fission factor isoform 1
NM_001276401.1	NP_001263330.1	mitochondrial fission factor isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase binding	IPI IPI: Inferred from physical interaction	23792689	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	23792689	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	23792689	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	23867156	RGD
involved in positive regulation of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	23867156	RGD
involved in positive regulation of mitochondrial fission	IMP IMP: Inferred from mutant phenotype	23867156	RGD
involved in positive regulation of synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	23792689	RGD
involved in protein targeting to mitochondrion	IMP IMP: Inferred from mutant phenotype	23792689	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial membrane	IMP IMP: Inferred from mutant phenotype	23792689	RGD
located in synaptic vesicle	IDA IDA: Inferred from direct assay	23792689	RGD
located in synaptic vesicle membrane	IMP IMP: Inferred from mutant phenotype	23792689	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

mitochondrial fission factor

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P6374	IIQLPEIVVV TFA		99.91%	Unkown
HY-P11005	P259	Inhibitor	/	Unkown
HY-RS08380	MFF Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19299	Mff Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25790	Mff Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	MFF	NCBI	NCBI:56947

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