2. Gene
  3. Trem2 - triggering receptor expressed on myeloid cells 2 Gene

Trem2 - triggering receptor expressed on myeloid cells 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Trem2-Mia; Trem2-Mib

Gene ID: 301227 | Gene type: protein coding

About Trem2

Summary

Predicted to enable several functions, including amyloid-beta binding activity; lipoprotein particle binding activity; and phospholipid binding activity. Involved in cellular response to glucose stimulus and cellular response to hypoxia. Predicted to be located in plasma membrane raft. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Orthologous to human TREM2 (triggering receptor expressed on myeloid cells 2). [provided by Alliance of Genome Resources, Apr 2022]

Trem2 Products(1)

mRNA Protein Name
NM_001106884.1 NP_001100354.1 triggering receptor expressed on myeloid cells 2 precursor
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
31900229 RGD
involved in cellular response to hypoxia IMP
IMP: Inferred from mutant phenotype
31900229 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

triggering receptor expressed on myeloid cells 2

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-W017540 Cyclocreatine Activator 99.78% Phase 1
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P991220 AL002 Agonist 98.01% Phase 2
HY-P990651 PY314 96.35% Phase 1
Pre-clinical Phase
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-160421 TREM2-IN-1 Inducer 99.34% Unkown
HY-RS15003 TREM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16526 Trem2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-169859 EP4 receptor antagonist 7 Antagonist / Unkown
HY-174369 TREM2 agonist-3 / Unkown
HY-174378 TREM2 agonist-4 Inhibitor / Unkown
HY-P10220 NOTA-COG1410 / Unkown
HY-W010270A Aurothiomalate disodium / Unkown
HY-W017540S Cyclocreatine-13C3 / Unkown
HY-RS22957 Trem2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990043 Iluzanebart 98.63% Unkown
HY-P991621 EOS006215 Inhibitor / Unkown
HY-P991174 Anti-TREM2 Antibody (AL2p-58) Inhibitor 97.43% Unkown
HY-P991442 DNL-919 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Trem2 NCBI NCBI:54209
Macaca fascicularis Trem2 NCBI NCBI:102133279
Mus musculus Trem2 NCBI NCBI:83433