2. Gene
  3. XRN1 - Xrn1 5'-3' exoribonuclease 1 Gene

XRN1 - Xrn1 5'-3' exoribonuclease 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as RGD1309713

Gene ID: 300944 | Gene type: protein coding

About XRN1

Summary

Predicted to enable 5'-3' exoribonuclease activity; G-quadruplex DNA binding activity; and G-quadruplex RNA binding activity. Involved in cellular response to organonitrogen compound; negative regulation of translation; and response to testosterone. Located in several cellular components, including P-body; dendrite; and neuronal cell body. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human XRN1 (5'-3' exoribonuclease 1). [provided by Alliance of Genome Resources, Apr 2022]

XRN1 Products(1)

mRNA Protein Name
NM_001305240.1 NP_001292169.1 5'-3' exoribonuclease 1
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to cycloheximide IEP
IEP: Inferred from expression pattern
25797256 RGD
involved in cellular response to puromycin IEP
IEP: Inferred from expression pattern
25736288 RGD
involved in negative regulation of translation IMP
IMP: Inferred from mutant phenotype
25797256 RGD
involved in response to testosterone IEP
IEP: Inferred from expression pattern
25797256 RGD
Cellular Component GO Annotation Evidence Reference Source
located in P-body IDA
IDA: Inferred from direct assay
22590546 RGD
located in dendrite IDA
IDA: Inferred from direct assay
25797256 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
25797256 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

5'-3' exoribonuclease 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-173593 Adenosine-3',5'-bisphosphate Inhibitor / Unkown
HY-RS15902 XRN1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS21461 Xrn1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS27979 Xrn1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens XRN1 NCBI NCBI:54464