Spdef - SAM pointed domain containing ets transcription factor Gene

Mus musculus

Also known as Pse; PDEF

Gene ID: 30051 | Gene type: protein coding

About Spdef

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Acts upstream of or within several processes, including columnar/cuboidal epithelial cell differentiation; positive regulation of cell fate commitment; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human SPDEF (SAM pointed domain containing ETS transcription factor). [provided by Alliance of Genome Resources, Apr 2022]

Spdef Products(4)

mRNA	Protein	Name
NM_001357728.1	NP_001344657.1	SAM pointed domain-containing Ets transcription factor
NM_001414277.1	NP_001401206.1	SAM pointed domain-containing Ets transcription factor
NM_001414278.1	NP_001401207.1	SAM pointed domain-containing Ets transcription factor
NM_013891.4	NP_038919.1	SAM pointed domain-containing Ets transcription factor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of cell fate commitment	IMP IMP: Inferred from mutant phenotype	19759516	MGI
acts upstream of epithelial cell fate commitment	IMP IMP: Inferred from mutant phenotype	19759516	MGI
acts upstream of or within glandular epithelial cell development	IMP IMP: Inferred from mutant phenotype	19549527	MGI
acts upstream of or within intestinal epithelial cell development	IMP IMP: Inferred from mutant phenotype	19549527	MGI
acts upstream of or within lung goblet cell differentiation	IDA IDA: Inferred from direct assay	17347682	MGI
acts upstream of or within negative regulation of cell fate commitment	IMP IMP: Inferred from mutant phenotype	19759516	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19759516	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19549527	MGI
acts upstream of or within positive regulation of cell fate commitment	IMP IMP: Inferred from mutant phenotype	19759516	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17347682	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	17347682	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19549527	MGI
acts upstream of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19759516	MGI
acts upstream of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	19759516	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19549527	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	17347682	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

SAM pointed domain-containing Ets transcription factor

prostate epithelium-specific Ets transcription factor	prostate specific ets transcription factor
prostate-derived Ets factor	prostate-specific Ets

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0603	Fluticasone	Agonist	98.70%	Yes

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13652	SPDEF Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17775	Spdef Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24242	Spdef Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Spdef	NCBI	NCBI:25803

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