2. Gene
  3. Shmt2 - serine hydroxymethyltransferase 2 Gene

Shmt2 - serine hydroxymethyltransferase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 299857 | Gene type: protein coding

About Shmt2

Summary

Enables several functions, including L-allo-threonine aldolase activity; glycine hydroxymethyltransferase activity; and pyridoxal phosphate binding activity. Involved in L-serine biosynthetic process; glycine biosynthetic process from serine; and positive regulation of cell population proliferation. Located in mitochondrial inner membrane; mitochondrial intermembrane space; and mitochondrial matrix. Orthologous to human SHMT2 (serine hydroxymethyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]

Shmt2 Products(3)

mRNA Protein Name
NM_001008322.2 NP_001008323.1 serine hydroxymethyltransferase, mitochondrial isoform 1
NM_001393833.1 NP_001380762.1 serine hydroxymethyltransferase, mitochondrial isoform 2
NM_001393834.1 NP_001380763.1 serine hydroxymethyltransferase, mitochondrial isoform 3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables L-allo-threonine aldolase activity IDA
IDA: Inferred from direct assay
3110140 RGD
enables amino acid binding IPI
IPI: Inferred from physical interaction
3110140 RGD
enables glycine hydroxymethyltransferase activity IDA
IDA: Inferred from direct assay
3110140 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
3110140 RGD
enables pyridoxal phosphate binding IDA
IDA: Inferred from direct assay
3110140 RGD
Biological Process GO Annotation Evidence Reference Source
involved in L-serine biosynthetic process IDA
IDA: Inferred from direct assay
10457370 RGD
involved in glycine biosynthetic process IDA
IDA: Inferred from direct assay
3110140 RGD
involved in glycine biosynthetic process from serine IDA
IDA: Inferred from direct assay
3110140 RGD
involved in glycine metabolic process IDA
IDA: Inferred from direct assay
10457370 RGD
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
12138190 RGD
Cellular Component GO Annotation Evidence Reference Source
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
4107181 RGD
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
4107181 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine hydroxymethyltransferase, mitochondrial

serine hydroxymethyltransferase 2 (mitochondrial)

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-129226 SHMT-IN-2 Inhibitor 99.60% Unkown
HY-134978 (Rac)-SHIN2 Inhibitor 99.09% Unkown
HY-148545 SHMT-IN-3 Inhibitor ≥98.0% Unkown
HY-RS12877 SHMT2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS17061 Shmt2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23505 Shmt2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Shmt2 NCBI NCBI:6472