2. Gene
  3. GNS - Gns glucosamine (N-acetyl)-6-sulfatase Gene

GNS - Gns glucosamine (N-acetyl)-6-sulfatase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 299825 | Gene type: protein coding

About GNS

Summary

Enables N-acetylglucosamine-6-sulfatase activity; glycosaminoglycan binding activity; and sulfate binding activity. Involved in keratan sulfate catabolic process. Located in lysosome. Human ortholog(s) of this gene implicated in mucopolysaccharidosis III and mucopolysaccharidosis type IIID. Orthologous to human GNS (glucosamine (N-acetyl)-6-sulfatase). [provided by Alliance of Genome Resources, Apr 2022]

GNS Products(1)

mRNA Protein Name
NM_001011989.1 NP_001011989.1 N-acetylglucosamine-6-sulfatase precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables N-acetylglucosamine-6-sulfatase activity IDA
IDA: Inferred from direct assay
3161730 RGD
enables glycosaminoglycan binding IPI
IPI: Inferred from physical interaction
3161730 RGD
enables sulfate binding IPI
IPI: Inferred from physical interaction
3161730 RGD
Biological Process GO Annotation Evidence Reference Source
involved in keratan sulfate catabolic process IDA
IDA: Inferred from direct assay
3161730 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

N-acetylglucosamine-6-sulfatase

N-acetylglucosamine-6-sulfatase-like

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-109061 Lazertinib Inhibitor 99.87% Unkown
Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-137978A Ezurpimtrostat hydrochloride 99.29% Phase 2
HY-137978 Ezurpimtrostat / Phase 2
Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-109061B Lazertinib mesylate Inhibitor 99.85% Unkown
HY-RS05581 GNS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19296 Gns Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25787 Gns Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens GNS NCBI NCBI:2799