Cyp11a1 - cytochrome P450, family 11, subfamily a, polypeptide 1 Gene

Rattus norvegicus

Also known as Cyp11a; Cypxia1; P450scc; P450(scc)

Gene ID: 29680 | Gene type: protein coding

About Cyp11a1

Summary

Enables Cholesterol binding activity and Cholesterol monooxygenase (side-chain-cleaving) activity. Involved in several processes, including nervous system development; response to vitamin; and steroid biosynthetic process. Located in mitochondrial crista and perikaryon. Biomarker of several diseases, including glucose metabolism disease (multiple); hypertension; nephrosis; sciatic neuropathy; and status epilepticus. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia and congenital adrenal insufficiency. Orthologous to human CYP11A1 (Cytochrome P450 family 11 subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]

Cyp11a1 Products(1)

mRNA	Protein	Name
NM_017286.3	NP_058982.1	cholesterol side-chain cleavage enzyme, mitochondrial precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in C21-steroid hormone biosynthetic process	IDA IDA: Inferred from direct assay	19665544	RGD
involved in Leydig cell differentiation	IEP IEP: Inferred from expression pattern	18502897	RGD
involved in Schwann cell differentiation	IEP IEP: Inferred from expression pattern	18373277	RGD
involved in biphenyl metabolic process	IEP IEP: Inferred from expression pattern	19071209	RGD
involved in cellular response to antibiotic	IEP IEP: Inferred from expression pattern	18655822	RGD
involved in cellular response to cAMP	IEP IEP: Inferred from expression pattern	17719163	RGD
involved in cellular response to cadmium ion	IEP IEP: Inferred from expression pattern	17719163	RGD
involved in cellular response to fibroblast growth factor stimulus	IEP IEP: Inferred from expression pattern	17494997	RGD
involved in cellular response to follicle-stimulating hormone stimulus	IEP IEP: Inferred from expression pattern	20810564	RGD
involved in cellular response to gonadotropin stimulus	IEP IEP: Inferred from expression pattern	9397943	RGD
involved in cellular response to interleukin-1	IEP IEP: Inferred from expression pattern	9397943	RGD
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	20665543	RGD
involved in cellular response to peptide hormone stimulus	IEP IEP: Inferred from expression pattern	19416745	RGD
involved in cellular response to transforming growth factor beta stimulus	IEP IEP: Inferred from expression pattern	18511507	RGD
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	9397943	RGD
involved in cerebellum development	IEP IEP: Inferred from expression pattern	16329132	RGD
involved in dibenzo-p-dioxin metabolic process	IEP IEP: Inferred from expression pattern	18637154	RGD
involved in granulosa cell differentiation	IEP IEP: Inferred from expression pattern	2176216	RGD
involved in hippocampus development	IEP IEP: Inferred from expression pattern	21047951	RGD
involved in male gonad development	IEP IEP: Inferred from expression pattern	18772241	RGD
involved in maternal process involved in female pregnancy	IEP IEP: Inferred from expression pattern	17726144	RGD
involved in mating behavior	IMP IMP: Inferred from mutant phenotype	16101892	RGD
involved in organic acid metabolic process	IEP IEP: Inferred from expression pattern	17400581	RGD
involved in phenol-containing compound metabolic process	IEP IEP: Inferred from expression pattern	18191889	RGD
involved in phthalate metabolic process	IEP IEP: Inferred from expression pattern	18923996	RGD
involved in response to L-ascorbic acid	IEP IEP: Inferred from expression pattern	17280759	RGD
involved in response to alkaloid	IEP IEP: Inferred from expression pattern	18772241	RGD
involved in response to amino acid	IEP IEP: Inferred from expression pattern	18040670	RGD
involved in response to cAMP	IEP IEP: Inferred from expression pattern	2176216	RGD
involved in response to cadmium ion	IEP IEP: Inferred from expression pattern	15223132	RGD
involved in response to corticosterone	IEP IEP: Inferred from expression pattern	18335507	RGD
involved in response to estrogen	IEP IEP: Inferred from expression pattern	12715917	RGD
involved in response to fungicide	IEP IEP: Inferred from expression pattern	14967917	RGD
involved in response to gamma radiation	IEP IEP: Inferred from expression pattern	18046538	RGD
involved in response to genistein	IEP IEP: Inferred from expression pattern	16214947	RGD
involved in response to gonadotropin	IEP IEP: Inferred from expression pattern	19929576	RGD
involved in response to hydrogen peroxide	IMP IMP: Inferred from mutant phenotype	14635199	RGD
involved in response to insecticide	IEP IEP: Inferred from expression pattern	19892000	RGD
involved in response to ionizing radiation	IEP IEP: Inferred from expression pattern	18821396	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	16844298	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	18606229	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	18609294	RGD
involved in response to salt stress	IEP IEP: Inferred from expression pattern	7678819	RGD
involved in response to steroid hormone	IEP IEP: Inferred from expression pattern	19961867	RGD
involved in response to vitamin E	IEP IEP: Inferred from expression pattern	17280759	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	20144211	RGD
involved in steroid biosynthetic process	IMP IMP: Inferred from mutant phenotype	17218406	RGD
involved in testosterone biosynthetic process	IEP IEP: Inferred from expression pattern	19883722	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial crista	IDA IDA: Inferred from direct assay	11691658	RGD
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	21075169	RGD
located in mitochondrion	IDA IDA: Inferred from direct assay	2170421	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	16632873	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cholesterol side-chain cleavage enzyme, mitochondrial

cholesterol desmolase	cholesterol side-chain cleavage cytochrome P450
cytochrome P450 11A1	cytochrome P450 11a cholesterol side chain cleavage
cytochrome P450 family 11 subfamily a	cytochrome P450 side-chain cleavage enzyme
cytochrome P450 subfamily

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16276	Osilodrostat	Inhibitor	99.90%	Yes
HY-16276A	Osilodrostat phosphate	Inhibitor	99.35%	Yes

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-156628	Opevesostat	Inhibitor	99.79%	Phase 3

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-130705A	Tachysterol 3		99.68%	Unkown
HY-156530	CYP11A1-IN-1	Inhibitor	99.64%	Unkown
HY-101217	BI 689648	Inhibitor	99.20%	Unkown
HY-135281	CYP11B2-IN-1	Inhibitor	99.83%	Unkown
HY-151140	CYP11B1-IN-2	Inhibitor	/	Unkown
HY-RS03434	CYP11A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03435	CYP11B1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-163751	STING-IN-9	Inhibitor	/	Unkown
HY-RS17315	Cyp11b1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17479	Cyp11a1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23770	Cyp11b1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23937	Cyp11a1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cyp11a1	NCBI	NCBI:1583

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