2. Gene
  3. Hmgcs1 - 3-hydroxy-3-methylglutaryl-CoA synthase 1 Gene

Hmgcs1 - 3-hydroxy-3-methylglutaryl-CoA synthase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 29637 | Gene type: protein coding

About Hmgcs1

Summary

Enables hydroxymethylglutaryl-CoA synthase activity; isomerase activity; and organic acid binding activity. Involved in several processes, including animal organ development; cellular response to cholesterol; and cellular response to follicle-stimulating hormone stimulus. Located in cytosol. Biomarker of obesity. Orthologous to human HMGCS1 (3-hydroxy-3-methylglutaryl-CoA synthase 1). [provided by Alliance of Genome Resources, Apr 2022]

Hmgcs1 Products(1)

mRNA Protein Name
NM_017268.2 NP_058964.1 hydroxymethylglutaryl-CoA synthase, cytoplasmic
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables hydroxymethylglutaryl-CoA synthase activity IDA
IDA: Inferred from direct assay
8094614 RGD
enables isomerase activity IDA
IDA: Inferred from direct assay
17764185 RGD
enables organic acid binding IDA
IDA: Inferred from direct assay
8094614 RGD
enables small molecule binding IDA
IDA: Inferred from direct assay
14984735 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to cholesterol IEP
IEP: Inferred from expression pattern
18303831 RGD
involved in cellular response to follicle-stimulating hormone stimulus IEP
IEP: Inferred from expression pattern
19196834 RGD
involved in cellular response to low-density lipoprotein particle stimulus IDA
IDA: Inferred from direct assay
16260 RGD
involved in cellular response to organic cyclic compound IEP
IEP: Inferred from expression pattern
9409294 RGD
involved in liver development IEP
IEP: Inferred from expression pattern
5166591 RGD
involved in male gonad development IEP
IEP: Inferred from expression pattern
11792726 RGD
involved in response to cholesterol IEP
IEP: Inferred from expression pattern
2903839 RGD
involved in response to gonadotropin IEP
IEP: Inferred from expression pattern
15459111 RGD
involved in response to hormone IEP
IEP: Inferred from expression pattern
8093833 RGD
involved in response to low light intensity stimulus IEP
IEP: Inferred from expression pattern
1683769 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
19527300 RGD
involved in response to purine-containing compound IDA
IDA: Inferred from direct assay
16260 RGD
involved in response to tellurium ion IEP
IEP: Inferred from expression pattern
10642751 RGD
involved in response to vitamin E IEP
IEP: Inferred from expression pattern
15753162 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
16020911 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hydroxymethylglutaryl-CoA synthase, cytoplasmic

3-hydroxy-3-methylglutaryl coenzyme A synthase

3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)

3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)

HMG-CoA synthase

hydroxymethylglutaryl-CoA synthase 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06241 HMGCS1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18093 Hmgcs1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24568 Hmgcs1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24905 Hmgcs2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hmgcs1 NCBI NCBI:3157