Atp2b1 - ATPase plasma membrane Ca2+ transporting 1 Gene

Rattus norvegicus

Also known as Pmca1a; Pmca1b; Pmca1c

Gene ID: 29598 | Gene type: protein coding

About Atp2b1

Summary

Enables PDZ domain binding activity. Involved in several processes, including calcium ion export; cellular response to lipid; and response to cold. Located in several cellular components, including basolateral plasma membrane; dendritic spine membrane; and neuronal cell body membrane. Is active in GABA-ergic synapse and glutamatergic synapse. Is integral component of presynaptic active zone membrane. Biomarker of hypertension. Orthologous to human ATP2B1 (ATPase plasma membrane Ca2+ transporting 1). [provided by Alliance of Genome Resources, Apr 2022]

Atp2b1 Products(3)

mRNA	Protein	Name
NM_001399339.1	NP_001386268.1	plasma membrane calcium-transporting ATPase 1 isoform 2
NM_001399343.1	NP_001386272.1	plasma membrane calcium-transporting ATPase 1 isoform 1
NM_053311.3	NP_445763.1	plasma membrane calcium-transporting ATPase 1 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	16554037	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in calcium ion export	IMP IMP: Inferred from mutant phenotype	9227424	RGD
involved in cellular response to corticosterone stimulus	IEP IEP: Inferred from expression pattern	10777776	RGD
involved in cellular response to vitamin D	IEP IEP: Inferred from expression pattern	11277270	RGD
involved in neural retina development	IEP IEP: Inferred from expression pattern	16079002	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in GABA-ergic synapse	EXP EXP: Inferred from Experiment	23622064	RGD
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	23622064	RGD
located in apical part of cell	IDA IDA: Inferred from direct assay	18395836	RGD
located in apical plasma membrane	IDA IDA: Inferred from direct assay	18395836	RGD
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	16803870	RGD
located in cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	20575074	RGD
located in dendrite membrane	IDA IDA: Inferred from direct assay	20575074	RGD
located in dendritic spine membrane	IDA IDA: Inferred from direct assay	20575074	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	23622064	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	23622064	RGD
located in neuronal cell body membrane	IDA IDA: Inferred from direct assay	20575074	RGD
is active in presynaptic active zone membrane	EXP EXP: Inferred from Experiment	23622064	RGD
is active in presynaptic active zone membrane	IDA IDA: Inferred from direct assay	23622064	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

plasma membrane calcium-transporting ATPase 1

ATPase, Ca++ transporting, plasma membrane 1	PMCA1
plasma membrane calcium ATPase	plasma membrane calcium pump

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01194	ATP2B1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20524	Atp2b1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27033	Atp2b1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Atp2b1	NCBI	NCBI:490

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