Hnrnpa1 - heterogeneous nuclear ribonucleoprotein A1 Gene

Rattus norvegicus

Also known as Hnrpa1; hnRNP A1

Gene ID: 29578 | Gene type: protein coding

About Hnrnpa1

Summary

Enables nucleic acid binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; cellular response to thapsigargin; and cellular response to tunicamycin. Located in cytosol and nucleoplasmic periphery of the nuclear pore complex. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 20; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 3; and tropical spastic paraparesis. Orthologous to several human genes including HNRNPA1L2 (heterogeneous nuclear ribonucleoprotein A1 like 2). [provided by Alliance of Genome Resources, Apr 2022]

Hnrnpa1 Products(2)

mRNA	Protein	Name
NM_001399274.1	NP_001386203.1	heterogeneous nuclear ribonucleoprotein A1 isoform 1
NM_017248.3	NP_058944.2	heterogeneous nuclear ribonucleoprotein A1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA/DNA annealing activity	IDA IDA: Inferred from direct assay	1703006	RGD
enables RNA binding	IDA IDA: Inferred from direct assay	23159318	RGD
enables RNA strand annealing activity	IDA IDA: Inferred from direct assay	1703006	RGD
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	11723238	RGD
enables mRNA binding	IDA IDA: Inferred from direct assay	23106379	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16518874	RGD
enables sequence-specific mRNA binding	IDA IDA: Inferred from direct assay	11886857	RGD
enables single-stranded RNA binding	IDA IDA: Inferred from direct assay	7727389	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to epidermal growth factor stimulus	IEP IEP: Inferred from expression pattern	3062579	RGD
involved in cellular response to potassium ion	IDA IDA: Inferred from direct assay	17298175	RGD
involved in lung development	IEP IEP: Inferred from expression pattern	9457472	RGD
involved in male gonad development	IEP IEP: Inferred from expression pattern	10978504	RGD
involved in positive regulation of action potential	IMP IMP: Inferred from mutant phenotype	15197740	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23106379	RGD
involved in response to endoplasmic reticulum stress	IEP IEP: Inferred from expression pattern	23106379	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleoplasmic periphery of the nuclear pore complex	IDA IDA: Inferred from direct assay	10633080	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

heterogeneous nuclear ribonucleoprotein A1

HDP	helix-destabilizing protein
hnRNP core protein A1	single-strand RNA-binding protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06261	HNRNPA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19543	Hnrnpa1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26039	Hnrnpa1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hnrnpa1	NCBI	NCBI:3178

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