2. Gene
  3. Skp2 - S-phase kinase associated protein 2 Gene

Skp2 - S-phase kinase associated protein 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as RGD1562456

Gene ID: 294790 | Gene type: protein coding

About Skp2

Summary

Predicted to enable identical protein binding activity. Involved in cellular response to cell-matrix adhesion and positive regulation of smooth muscle cell proliferation. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of SCF ubiquitin Ligase complex. Predicted to be active in cytosol and nucleus. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human SKP2 (S-phase kinase associated protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Skp2 Products(1)

mRNA Protein Name
NM_001106416.2 NP_001099886.1 S-phase kinase-associated protein 2
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
19533683 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to cell-matrix adhesion IEP
IEP: Inferred from expression pattern
11425869 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
19878790 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

S-phase kinase-associated protein 2

S-phase kinase-associated protein 2 (p45)

S-phase kinase-associated protein 2, E3 ubiquitin protein ligase

Related Agents

Pre-clinical Phase
Bioactive Molecules (14)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100237 SZL P1-41 99.07% Unkown
HY-16661 Skp2 Inhibitor C1 Inhibitor 98.21% Unkown
HY-135199 Ubiquitination-IN-1 Inhibitor 99.84% Unkown
HY-N0704 Agrimol B 99.75% Unkown
HY-112158 NSC139021 Inhibitor 99.86% Unkown
HY-15694 SMIP004 99.79% Unkown
HY-148900 SCFSkp2-IN-2 Inhibitor 99.01% Unkown
HY-123578 NSC689857 Inhibitor 99.65% Unkown
HY-153937 Skp2 inhibitor 2 Inhibitor 99.67% Unkown
HY-149954 SARS-CoV-2-IN-39 Inhibitor 99.79% Unkown
HY-162938 Skp2 inhibitor 3 Inhibitor 98.07% Unkown
HY-RS12974 SKP2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS16925 Skp2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23368 Skp2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Skp2 NCBI NCBI:6502