Aoc3 - amine oxidase, copper containing 3 Gene

Rattus norvegicus

Also known as SSAO

Gene ID: 29473 | Gene type: protein coding

About Aoc3

Summary

Enables identical protein binding activity and primary amine oxidase activity. Involved in several processes, including eating behavior; leukocyte migration involved in inflammatory response; and positive regulation of glucose transmembrane transport. Located in extracellular space and intracellular membrane-bounded organelle. Used to study aortic aneurysm; obesity; type 2 diabetes mellitus; and uveitis. Biomarker of intracranial aneurysm. Orthologous to human AOC3 (amine oxidase copper containing 3). [provided by Alliance of Genome Resources, Apr 2022]

Aoc3 Products(1)

mRNA	Protein	Name
NM_031582.3	NP_113770.2	membrane primary amine oxidase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	17393059	RGD
enables primary methylamine oxidase activity	IDA IDA: Inferred from direct assay	17393059	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in eating behavior	IMP IMP: Inferred from mutant phenotype	17977742	RGD
involved in leukocyte migration involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	17993604	RGD
involved in positive regulation of D-glucose transmembrane transport	IDA IDA: Inferred from direct assay	15000445	RGD
involved in positive regulation of acute inflammatory response	IMP IMP: Inferred from mutant phenotype	17993604	RGD
involved in positive regulation of leukocyte migration	IMP IMP: Inferred from mutant phenotype	19635478	RGD
involved in regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	17385063	RGD
involved in response to immobilization stress	IMP IMP: Inferred from mutant phenotype	11099833	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	10048142	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

membrane primary amine oxidase

VAP-1	VP97
copper amine oxidase	semicarbazide-sensitive amine oxidase
vascular adhesion protein 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00773	AOC3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17943	Aoc3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24414	Aoc3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99323	Timolumab	Inhibitor	98.56%	Unkown
HY-P99526	Vapaliximab	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Aoc3	NCBI	NCBI:8639

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