Trpv2 - transient receptor potential cation channel, subfamily V, member 2 Gene

Rattus norvegicus

Also known as Vrl1

Gene ID: 29465 | Gene type: protein coding

About Trpv2

Summary

Enables identical protein binding activity. Involved in negative regulation of cell population proliferation and response to heat. Located in several cellular components, including endomembrane system; lamellipodium; and plasma membrane. Orthologous to human TRPV2 (transient receptor potential cation channel subfamily V member 2). [provided by Alliance of Genome Resources, Apr 2022]

Trpv2 Products(3)

mRNA	Protein	Name
NM_001270797.1	NP_001257726.1	transient receptor potential cation channel subfamily V member 2
NM_001270798.1	NP_001257727.1	transient receptor potential cation channel subfamily V member 2
NM_017207.3	NP_058903.2	transient receptor potential cation channel subfamily V member 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium channel activity	IDA IDA: Inferred from direct assay	1524959	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	24373766	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	14991772	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	25869297	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in endomembrane system	IDA IDA: Inferred from direct assay	14991772	RGD
located in lamellipodium	IDA IDA: Inferred from direct assay	25869297	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	14991772	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transient receptor potential cation channel subfamily V member 2

OTRPC2	VRL-1
osm-9-like TRP channel 2	stretch-activated channel 2B
vanilloid receptor-like protein 1

Trpv2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Trpv2	Q9WUD2	Trpv2	Rattus norvegicus	Q9WUD2	Comig Non-Denat Gel	24373766
Intra	Trpv2	Q9WUD2	Trpv2	Rattus norvegicus	Q9WUD2	GMS	24373766
Intra	Trpv2	Q9WUD2	Trpv2	Rattus norvegicus	Q9WUD2	3D-EM	24373766

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0545	Probenecid		99.92%	Yes

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-132222	SET2	Antagonist	99.78%	Unkown
HY-157131	TRPV2-selective blocker 1	Inhibitor	99.84%	Unkown
HY-N8264	Moringin	Agonist	99.95%	Unkown
HY-B0545R	Probenecid (Standard)		99.00%	Unkown
HY-W404916	Probenecid sodium		99.37%	Unkown
HY-RS15122	TRPV2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-B0545S	Probenecid-d14		99.0%	Unkown
HY-N3230	Murpanicin	Inhibitor	/	Unkown
HY-RS17234	Trpv2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23687	Trpv2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Trpv2	NCBI	NCBI:51393

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