2. Gene
  3. Ghrh - growth hormone releasing hormone Gene

Ghrh - growth hormone releasing hormone Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as GHRF

Gene ID: 29446 | Gene type: protein coding

About Ghrh

Summary

Enables growth hormone-releasing hormone activity. Involved in several processes, including circadian sleep/wake cycle, non-REM sleep; growth hormone secretion; and positive regulation of cell communication. Located in axon terminus; extracellular space; and perikaryon. Used to study myocardial infarction and prostatic hypertrophy. Biomarker of sleep disorder. Human ortholog(s) of this gene implicated in autoimmune polyendocrine syndrome type 1; endometrial cancer; ovarian cancer; and renal cell carcinoma. Orthologous to human GHRH (growth hormone releasing hormone). [provided by Alliance of Genome Resources, Apr 2022]

Ghrh Products(1)

mRNA Protein Name
NM_031577.1 NP_113765.1 somatoliberin precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables growth hormone-releasing hormone activity IDA
IDA: Inferred from direct assay
12446584 RGD
Biological Process GO Annotation Evidence Reference Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
12446584 RGD
involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
14664705 RGD
involved in cellular response to interleukin-6 IEP
IEP: Inferred from expression pattern
19239705 RGD
involved in negative regulation of cardiac muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
19293247 RGD
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
14664705 RGD
involved in positive regulation of cAMP/PKA signal transduction IDA
IDA: Inferred from direct assay
10579333 RGD
involved in positive regulation of circadian sleep/wake cycle, non-REM sleep IMP
IMP: Inferred from mutant phenotype
19889861 RGD
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
12213318 RGD
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
18363807 RGD
involved in positive regulation of growth hormone secretion IDA
IDA: Inferred from direct assay
6130528 RGD
involved in response to dexamethasone IEP
IEP: Inferred from expression pattern
22067322 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
21180161 RGD
involved in response to leptin IEP
IEP: Inferred from expression pattern
18806317 RGD
Cellular Component GO Annotation Evidence Reference Source
located in axon terminus IDA
IDA: Inferred from direct assay
6423368 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
1537276 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
6423368 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

somatoliberin

GRF

growth hormone-releasing factor

Related Agents

Pre-clinical Phase
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P3304 MR 409 Activator 99.51% Unkown
HY-P0089A Human growth hormone-releasing factor TFA 99.66% Unkown
HY-P0089 Human growth hormone-releasing factor / Unkown
HY-P3397A JV-1-36 acetate Antagonist 99.27% Unkown
HY-P3397 JV-1-36 Antagonist / Unkown
HY-P3594 [His1,Nle27] GHRF (1-32), amide, human / Unkown
HY-P3595 GHRF, porcine / Unkown
HY-RS05413 GHRH Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS16752 Ghrh Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23191 Ghrh Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ghrh NCBI NCBI:2691