2. Gene
  3. Aif1 - allograft inflammatory factor 1 Gene

Aif1 - allograft inflammatory factor 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as iba1; Bart1; mrf-1; BART-1

Gene ID: 29427 | Gene type: protein coding

About Aif1

Summary

Predicted to enable actin filament binding activity and calcium ion binding activity. Involved in several processes, including cellular response to morphine; positive regulation of muscle hyperplasia; and positive regulation of nitrogen compound metabolic process. Located in cytosol; lamellipodium; and perikaryon. Used to study type 1 diabetes mellitus. Biomarker of brain disease (multiple); glomerulonephritis; meningoencephalitis; and motor neuron disease. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human AIF1 (allograft inflammatory factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Aif1 Products(1)

mRNA Protein Name
NM_017196.3 NP_058892.1 allograft inflammatory factor 1
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to hormone stimulus IEP
IEP: Inferred from expression pattern
7769138 RGD
involved in cellular response to hydroperoxide IEP
IEP: Inferred from expression pattern
16877440 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
18717813 RGD
involved in cellular response to morphine IEP
IEP: Inferred from expression pattern
19176808 RGD
involved in cellular response to type II interferon IEP
IEP: Inferred from expression pattern
7769138 RGD
involved in cerebellum development IEP
IEP: Inferred from expression pattern
9698327 RGD
involved in inflammatory response IEP
IEP: Inferred from expression pattern
7769138 RGD
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
16157606 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16157606 RGD
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
16157606 RGD
involved in positive regulation of cell migration IDA
IDA: Inferred from direct assay
16157606 RGD
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
16157606 RGD
involved in positive regulation of muscle hyperplasia IMP
IMP: Inferred from mutant phenotype
18779232 RGD
involved in positive regulation of nitric oxide biosynthetic process IDA
IDA: Inferred from direct assay
16157606 RGD
involved in positive regulation of nitric oxide biosynthetic process IMP
IMP: Inferred from mutant phenotype
16157606 RGD
involved in positive regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
18779232 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
18779232 RGD
involved in response to axon injury IEP
IEP: Inferred from expression pattern
19331524 RGD
involved in response to cytokine IEP
IEP: Inferred from expression pattern
17394154 RGD
involved in response to electrical stimulus IEP
IEP: Inferred from expression pattern
19410369 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
17265048 RGD
Cellular Component GO Annotation Evidence Reference Source
located in cell projection IDA
IDA: Inferred from direct assay
19249294 RGD
located in cytoplasm IDA
IDA: Inferred from direct assay
7769138 RGD
located in lamellipodium IDA
IDA: Inferred from direct assay
16877440 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
19249294 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

allograft inflammatory factor 1

AIF-1

balloon angioplasty responsive transcript

balloon angioplasty-responsive transcript 1

ionized calcium binding adapter molecule 1

microglia response factor

protein BART-1

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-113915 Kuguaglycoside C Inducer / Unkown
HY-RS00490 AIF1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00491 AIF1L Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS17578 Aif1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24038 Aif1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aif1 NCBI NCBI:199
Macaca fascicularis Aif1 NCBI NCBI:102132908
Mus musculus Aif1 NCBI NCBI:11629