2. Gene
  3. Htt - huntingtin Gene

Htt - huntingtin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Hd; Hdh

Gene ID: 29424 | Gene type: protein coding

About Htt

Summary

Enables signaling receptor binding activity. Involved in several processes, including mRNA transport; negative regulation of cysteine-type endopeptidase activity; and regulation of intracellular mRNA localization. Located in several cellular components, including neuronal cell body; neuronal ribonucleoprotein granule; and postsynaptic density. Used to study Huntington's disease. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in Huntington's disease and Parkinson's disease. Orthologous to human HTT (Huntingtin). [provided by Alliance of Genome Resources, Apr 2022]

Htt Products(1)

mRNA Protein Name
NM_024357.4 NP_077333.2 huntingtin
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
9454836 RGD
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
12873381 RGD
Biological Process GO Annotation Evidence Reference Source
involved in mRNA transport IMP
IMP: Inferred from mutant phenotype
22355657 RGD
involved in microtubule depolymerization IMP
IMP: Inferred from mutant phenotype
20858895 RGD
involved in negative regulation of cysteine-type endopeptidase activity IMP
IMP: Inferred from mutant phenotype
17124493 RGD
involved in regulation of intracellular mRNA localization IMP
IMP: Inferred from mutant phenotype
20185826 RGD
Cellular Component GO Annotation Evidence Reference Source
located in axon IDA
IDA: Inferred from direct assay
22355657 RGD
located in clathrin-coated vesicle IDA
IDA: Inferred from direct assay
20739295 RGD
located in dendrite IDA
IDA: Inferred from direct assay
22355657 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
22355657 RGD
located in neuronal ribonucleoprotein granule IDA
IDA: Inferred from direct assay
22355657 RGD
located in synaptic membrane IDA
IDA: Inferred from direct assay
12650982 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

huntingtin

HD protein homolog

Huntington disease gene homolog

huntingtin (Huntington disease)

huntington disease protein homolog

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-132579 Tominersen 94.13% Phase 3
HY-132593 Rovanersen / Phase 2
Pre-clinical Phase
Bioactive Molecules (17)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16009 Buntanetap 99.71% Unkown
HY-156650 Votoplam Modulator 99.51% Unkown
HY-132579A Tominersen sodium 97.36% Unkown
HY-136780 SEN177 Inhibitor 98.76% Unkown
HY-156103 mHTT-IN-2 Inhibitor 99.35% Unkown
HY-150236 FITC-labeled Tominersen sodium Inhibitor 95.72% Unkown
HY-132593A Rovanersen sodium 95.58% Unkown
HY-16009B Buntanetap L-Tartrate 98.93% Unkown
HY-143792 HTT-D3 Inhibitor / Unkown
HY-10542A (Z)-GW 5074 Inhibitor / Unkown
HY-P10822 ED11 Inhibitor / Unkown
HY-RS06490 HTT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13311 SLC6A4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13312 Slc6a4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W792458 MADAM Ligand / Unkown
HY-RS18021 Htt Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24494 Htt Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Htt NCBI NCBI:3064