Urod - uroporphyrinogen decarboxylase Gene

Rattus norvegicus

Also known as porphyrinogen carboxy-lyase

Gene ID: 29421 | Gene type: protein coding

About Urod

Summary

Enables ferrous iron binding activity and uroporphyrinogen decarboxylase activity. Involved in several processes, including porphyrin-containing compound metabolic process; response to estradiol; and response to fungicide. Located in cytosol. Biomarker of porphyria and porphyria cutanea tarda. Human ortholog(s) of this gene implicated in porphyria cutanea tarda. Orthologous to human UROD (uroporphyrinogen decarboxylase). [provided by Alliance of Genome Resources, Apr 2022]

Urod Products(1)

mRNA	Protein	Name
NM_019209.1	NP_062082.1	uroporphyrinogen decarboxylase

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables ferrous iron binding	IDA IDA: Inferred from direct assay	515872	RGD
enables uroporphyrinogen decarboxylase activity	IDA IDA: Inferred from direct assay	15736160	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to arsenic-containing substance	IEP IEP: Inferred from expression pattern	10416273	RGD
involved in liver development	IEP IEP: Inferred from expression pattern	6219675	RGD
involved in porphyrin-containing compound biosynthetic process	IDA IDA: Inferred from direct assay	12381387	RGD
involved in response to amine	IEP IEP: Inferred from expression pattern	10365252	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	3945969	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	12426626	RGD
involved in response to fungicide	IEP IEP: Inferred from expression pattern	19482825	RGD
involved in response to iron ion	IEP IEP: Inferred from expression pattern	891100	RGD
involved in response to mercury ion	IEP IEP: Inferred from expression pattern	6482878	RGD
involved in response to methylmercury	IEP IEP: Inferred from expression pattern	3327437	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	4023421	RGD
involved in uroporphyrinogen III metabolic process	IDA IDA: Inferred from direct assay	15736160	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

uroporphyrinogen decarboxylase

UPD	URO-D
porphyrinogen carboxylase	uroporphyrinogen III decarboxylase

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15509	UROD Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21453	Urod Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27971	Urod Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Urod	NCBI	NCBI:7389

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