Uts2 - urotensin 2 Gene

Rattus norvegicus

Also known as Ucn2

Gene ID: 29180 | Gene type: protein coding

About Uts2

Summary

Predicted to enable hormone activity. Involved in several processes, including negative regulation of secretion; regulation of blood pressure; and regulation of heart rate. Located in extracellular space. Used to study hypertension. Biomarker of asthma; cardiomyopathy; endomyocardial fibrosis; myocardial infarction; and pulmonary hypertension. Human ortholog(s) of this gene implicated in gestational diabetes and type 2 diabetes mellitus. Orthologous to human UTS2 (urotensin 2). [provided by Alliance of Genome Resources, Apr 2022]

Uts2 Products(1)

mRNA	Protein	Name
NM_019160.2	NP_062033.1	urotensin-2 precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in blood vessel diameter maintenance	IDA IDA: Inferred from direct assay	17097764	RGD
involved in negative regulation of blood pressure	IDA IDA: Inferred from direct assay	12217424	RGD
involved in negative regulation of glomerular filtration	IDA IDA: Inferred from direct assay	16531985	RGD
involved in negative regulation of heart rate	IDA IDA: Inferred from direct assay	12217424	RGD
involved in negative regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	17931748	RGD
involved in negative regulation of urine volume	IDA IDA: Inferred from direct assay	16531985	RGD
involved in positive regulation of angiogenesis	IDA IDA: Inferred from direct assay	17089015	RGD
involved in positive regulation of blood pressure	IDA IDA: Inferred from direct assay	12217424	RGD
involved in positive regulation of cell differentiation	IDA IDA: Inferred from direct assay	18475149	RGD
involved in positive regulation of circadian sleep/wake cycle, REM sleep	IDA IDA: Inferred from direct assay	15944374	RGD
involved in positive regulation of circadian sleep/wake cycle, wakefulness	IDA IDA: Inferred from direct assay	15944374	RGD
involved in positive regulation of collagen biosynthetic process	IDA IDA: Inferred from direct assay	17184580	RGD
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	18082287	RGD
involved in positive regulation of fibroblast migration	IDA IDA: Inferred from direct assay	18475149	RGD
involved in positive regulation of fibroblast proliferation	IDA IDA: Inferred from direct assay	17184580	RGD
involved in positive regulation of heart rate	IDA IDA: Inferred from direct assay	12217424	RGD
involved in positive regulation of synaptic transmission, cholinergic	IDA IDA: Inferred from direct assay	15944374	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	16677483	RGD
involved in response to testosterone	IEP IEP: Inferred from expression pattern	12421619	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	17184580	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	17184580	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

urotensin-2

U-II	UII
urocortin 2	urotensin II

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15583	UTS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS15584	UTS2R Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS15585	Uts2r Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS15586	Uts2r Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20833	Uts2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27347	Uts2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Uts2	NCBI	NCBI:10911

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