Capn1 - calpain 1 Gene

Rattus norvegicus

Gene ID: 29153 | Gene type: protein coding

About Capn1

Summary

Enables several functions, including calcium ion binding activity; calcium-dependent cysteine-type endopeptidase activity; and cytoskeletal protein binding activity. Involved in several processes, including negative regulation of NIK/NF-kappaB signaling; positive regulation of cardiac muscle cell apoptotic process; and positive regulation of leukocyte tethering or rolling. Located in cytosol; membrane; and mitochondrion. Biomarker of acute kidney failure; aortic atherosclerosis; epilepsy; and sciatic neuropathy. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 76. Orthologous to human CAPN1 (calpain 1). [provided by Alliance of Genome Resources, Apr 2022]

Capn1 Products(1)

mRNA	Protein	Name
NM_019152.2	NP_062025.1	calpain-1 catalytic subunit

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium ion binding	IMP IMP: Inferred from mutant phenotype	11893336	RGD
enables calcium-dependent cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	17429681	RGD
enables calcium-dependent cysteine-type endopeptidase activity	IMP IMP: Inferred from mutant phenotype	11893336	RGD
enables cytoskeletal protein binding	IDA IDA: Inferred from direct assay	17429681	RGD
enables enzyme binding	IPI IPI: Inferred from physical interaction	20850499	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	18559257	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to hydrogen peroxide	IMP IMP: Inferred from mutant phenotype	22402252	RGD
involved in negative regulation of actin filament polymerization	IMP IMP: Inferred from mutant phenotype	25653381	RGD
involved in negative regulation of non-canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	21415394	RGD
involved in positive regulation of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	22402252	RGD
involved in positive regulation of leukocyte tethering or rolling	IMP IMP: Inferred from mutant phenotype	21415394	RGD
involved in positive regulation of vascular permeability	IMP IMP: Inferred from mutant phenotype	21415394	RGD
involved in protein autoprocessing	IDA IDA: Inferred from direct assay	17182728	RGD
involved in protein catabolic process	IDA IDA: Inferred from direct assay	17429681	RGD
involved in protein catabolic process	IMP IMP: Inferred from mutant phenotype	11893336	RGD
involved in protein catabolic process at postsynapse	EXP EXP: Inferred from Experiment	10825658	RGD
involved in protein catabolic process at postsynapse	IDA IDA: Inferred from direct assay	10825658	RGD
involved in protein catabolic process at postsynapse	IEP IEP: Inferred from expression pattern	10825658	RGD
involved in protein catabolic process at postsynapse	IMP IMP: Inferred from mutant phenotype	24285894	RGD
involved in proteolysis	IDA IDA: Inferred from direct assay	22711986	RGD
involved in response to angiotensin	IMP IMP: Inferred from mutant phenotype	21415394	RGD
involved in response to arsenic-containing substance	IEP IEP: Inferred from expression pattern	24641850	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	10688895	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	10688895	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	10688895	RGD
is active in postsynapse	IMP IMP: Inferred from mutant phenotype	10688895	RGD
is active in postsynaptic density	IDA IDA: Inferred from direct assay	2843999	RGD
is active in presynapse	IDA IDA: Inferred from direct assay	2843999	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

calpain-1 catalytic subunit

CANP 1	calcium-activated neutral proteinase 1
calpain 1, (mu/I) large subunit	calpain mu-type
calpain-1 large subunit	micromolar-calpain
muCANP

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-158022	CTSL/CAPN1-IN-1	Inhibitor	/	Unkown
HY-161342	CTSL/CAPN1-IN-2	Inhibitor	/	Unkown
HY-RS01883	CAPN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01895	CAPNS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17903	Capn1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24372	Capn1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Capn1	NCBI	NCBI:823
Mus musculus	Capn1	NCBI	NCBI:12333

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