Nqo2 - N-ribosyldihydronicotinamide:quinone reductase 2 Gene

Rattus norvegicus

Gene ID: 291084 | Gene type: protein coding

About Nqo2

Summary

Predicted to enable several functions, including anion binding activity; dihydronicotinamide riboside Quinone Reductase activity; and melatonin binding activity. Involved in several processes, including positive regulation of ERK1 and ERK2 cascade; positive regulation of neuron apoptotic process; and positive regulation of vascular associated smooth muscle cell proliferation. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Parkinson's disease; agranulocytosis; breast cancer; and breast carcinoma. Orthologous to human NQO2 (N-ribosyldihydronicotinamide:quinone reductase 2). [provided by Alliance of Genome Resources, Apr 2022]

Nqo2 Products(1)

mRNA	Protein	Name
NM_001004214.1	NP_001004214.1	ribosyldihydronicotinamide dehydrogenase [quinone]

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in memory	IEP IEP: Inferred from expression pattern	17512093	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	23554738	RGD
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	20861374	RGD
involved in positive regulation of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	23554738	RGD
involved in positive regulation of vascular associated smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	22508052	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ribosyldihydronicotinamide dehydrogenase [quinone]

NAD(P)H dehydrogenase, quinone 2	NAD(P)H quinone dehydrogenase 2
NRH dehydrogenase [quinone] 2	NRH:quinone oxidoreductase 2
QR2	quinone reductase 2
ribosyldihydronicotinamide dehydrogenase

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14895	Fabomotizole		99.96%	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-145820	Tubulin inhibitor 14		/	Phase 3
HY-12346	FH1	Inhibitor	99.17%	Phase 1

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-77521	Dabigatran ethyl ester hydrochloride	Inhibitor	/	Unkown
HY-168926	NQO2-IN-1	Inducer	98.02%	Unkown
HY-RS09524	NQO2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20312	Nqo2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26820	Nqo2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nqo2	NCBI	NCBI:4835

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