2. Gene
  3. Col4a1 - collagen type IV alpha 1 chain Gene

Col4a1 - collagen type IV alpha 1 chain Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 290905 | Gene type: protein coding

About Col4a1

Summary

Predicted to enable platelet-derived growth factor binding activity. Predicted to be an extracellular matrix structural constituent conferring tensile strength. Involved in epithelial cell differentiation. Predicted to be located in extracellular region. Predicted to be part of Collagen type IV trimer. Predicted to be active in basement membrane and extracellular space. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in brain small vessel disease 1; myocardial infarction; and retinal arterial tortuosity. Orthologous to human COL4A1 (Collagen type IV alpha 1 chain). [provided by Alliance of Genome Resources, Apr 2022]

Col4a1 Products(1)

mRNA Protein Name
NM_001135009.1 NP_001128481.1 collagen alpha-1(IV) chain precursor
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in epithelial cell differentiation IEP
IEP: Inferred from expression pattern
8635488 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

collagen alpha-1(IV) chain

alpha 1 type IV collagen

collagen, type IV, alpha 1

procollagen, type IV, alpha 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02983 COL4A1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS19056 Col4a1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25546 Col4a1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Col4a1 NCBI NCBI:1282