2. Gene
  3. Kiss1 - KiSS-1 metastasis-suppressor Gene

Kiss1 - KiSS-1 metastasis-suppressor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Eseptin

Gene ID: 289023 | Gene type: protein coding

About Kiss1

Summary

Enables Kisspeptin Receptor binding activity. Involved in several processes, including generation of ovulation cycle rhythm; positive regulation of cell communication; and positive regulation of cytosolic calcium ion concentration involved in Phospholipase C-activating G protein-coupled signaling pathway. Located in several cellular components, including apical plasma membrane; extracellular space; and neuronal cell body. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 13 with or without anosmia. Orthologous to human KISS1 (KiSS-1 metastasis suppressor). [provided by Alliance of Genome Resources, Apr 2022]

Kiss1 Products(2)

mRNA Protein Name
NM_001412625.1 NP_001399554.1 metastasis-suppressor KiSS-1 precursor
NM_181692.2 NP_859043.1 metastasis-suppressor KiSS-1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables kisspeptin receptor binding IPI
IPI: Inferred from physical interaction
11457843 RGD
Biological Process GO Annotation Evidence Reference Source
involved in generation of ovulation cycle rhythm IMP
IMP: Inferred from mutant phenotype
15976058 RGD
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
11457843 RGD
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
11457843 RGD
involved in positive regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
16222076 RGD
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
17532794 RGD
involved in positive regulation of growth hormone secretion IDA
IDA: Inferred from direct assay
17532794 RGD
involved in positive regulation of luteinizing hormone secretion IDA
IDA: Inferred from direct assay
17532794 RGD
involved in positive regulation of luteinizing hormone secretion IMP
IMP: Inferred from mutant phenotype
17213691 RGD
NOT involved in positive regulation of stress-activated MAPK cascade IMP
IMP: Inferred from mutant phenotype
16222076 RGD
involved in positive regulation of synaptic transmission IDA
IDA: Inferred from direct assay
16222076 RGD
Cellular Component GO Annotation Evidence Reference Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
17503086 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
16339453 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
15976058 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

metastasis-suppressor KiSS-1

Kiss1 variant E1a-E2b-E3

Kiss1 variant E1b-E2a-E3

Kiss1 variant E1b-E2b-E3

MLL septin-like fusion

kisspeptin-1

metastin

Related Agents

Clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-P0076A TAK-448 acetate 99.70% Phase 2
HY-P0076 TAK-448 99.90% Phase 2
HY-P2161 TAK-683 / Phase 1
Pre-clinical Phase
Bioactive Molecules (16)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P1022 Kisspeptin-54(human) 98.00% Unkown
HY-P1196A Kisspeptin 234 TFA Antagonist 98.92% Unkown
HY-P1197A Kisspeptin-10 (mouse, rat) (TFA) 97.44% Unkown
HY-P10489 Kisspeptin-14 human 99.84% Unkown
HY-P2161B TAK-683 acetate 99.91% Unkown
HY-P1022A Kisspeptin-54(human) TFA 98.86% Unkown
HY-P1196 Kisspeptin 234 Antagonist / Unkown
HY-P1197 Kisspeptin-10 (mouse, rat) 99.53% Unkown
HY-P2161A TAK-683 TFA / Unkown
HY-P2191 KISS1-305 / Unkown
HY-RS07315 KISS1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS07316 KISS1R Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS07317 Kiss1r Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS07318 Kiss1r Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18527 Kiss1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25009 Kiss1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kiss1 NCBI NCBI:3814