2. Gene
  3. Abca3 - ATP-binding cassette, sub-family A (ABC1), member 3 Gene

Abca3 - ATP-binding cassette, sub-family A (ABC1), member 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Abc3; ABC-C; 1810036E22Rik

Gene ID: 27410 | Gene type: protein coding

About Abca3

Summary

Predicted to enable ABC-type xenobiotic transporter activity; phosphatidylcholine flippase activity; and phosphatidylcholine transfer activity. Involved in several processes, including glycerophospholipid metabolic process; phospholipid homeostasis; and surfactant homeostasis. Located in alveolar lamellar body membrane. Is expressed in several structures, including cardiovascular system; genitourinary system; gut; nervous system; and respiratory system. Used to study pulmonary alveolar proteinosis. Human ortholog(s) of this gene implicated in pulmonary alveolar proteinosis. Orthologous to human ABCA3 (ATP binding cassette subfamily A member 3). [provided by Alliance of Genome Resources, Apr 2022]

Abca3 Products(2)

mRNA Protein Name
NM_001039581.2 NP_001034670.1 phospholipid-transporting ATPase ABCA3
NM_013855.3 NP_038883.2 phospholipid-transporting ATPase ABCA3
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in lung development IMP
IMP: Inferred from mutant phenotype
17540762 MGI
involved in organelle assembly IMP
IMP: Inferred from mutant phenotype
17540762 MGI
involved in phosphatidylcholine metabolic process IMP
IMP: Inferred from mutant phenotype
17267394 MGI
involved in phosphatidylglycerol metabolic process IMP
IMP: Inferred from mutant phenotype
17142808 MGI
involved in phospholipid homeostasis IMP
IMP: Inferred from mutant phenotype
20190032 MGI
involved in regulation of lipid biosynthetic process IMP
IMP: Inferred from mutant phenotype
20190032 MGI
involved in regulation of lipid transport IMP
IMP: Inferred from mutant phenotype
20190032 MGI
involved in surfactant homeostasis IMP
IMP: Inferred from mutant phenotype
17142808 MGI
Cellular Component GO Annotation Evidence Reference Source
located in alveolar lamellar body membrane IDA
IDA: Inferred from direct assay
11940594 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

phospholipid-transporting ATPase ABCA3

ATP-binding cassette sub-family A member 3

xenobiotic-transporting ATPase ABCA3

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00041 ABCA3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS20843 Abca3 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS27357 Abca3 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Abca3 NCBI NCBI:21