Abcg5 - ATP binding cassette subfamily G member 5 Gene

Mus musculus

Also known as cmp; trac; sterolin-1

Gene ID: 27409 | Gene type: protein coding

About Abcg5

Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily, and functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. Disruption of this gene in mice results in thrombocytopenia, prolonged bleeding times, anemia, leukopenia, infertility, shortened life span and cardiomyopathy. Mice lacking this gene show symptoms of sitosterolemia. [provided by RefSeq, Nov 2015]

Abcg5 Products(1)

mRNA	Protein	Name
NM_031884.2	NP_114090.1	ATP-binding cassette sub-family G member 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to cholesterol transfer activity	IMP IMP: Inferred from mutant phenotype	14504269	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12208867	MGI
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	12208867	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cholesterol efflux	IMP IMP: Inferred from mutant phenotype	14504269	MGI
involved in sterol transport	IDA IDA: Inferred from direct assay	16867993	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical part of cell	IDA IDA: Inferred from direct assay	15040800	MGI
located in apical plasma membrane	IDA IDA: Inferred from direct assay	12208867	MGI
located in apical plasma membrane	IMP IMP: Inferred from mutant phenotype	14504269	MGI
located in membrane	IDA IDA: Inferred from direct assay	15040800	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	12208867	MGI
part of receptor complex	IDA IDA: Inferred from direct assay	14504269	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ATP-binding cassette sub-family G member 5

ATP-binding cassette, sub-family G (WHITE), member 5

sterolin 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0288	Lycorine		99.87%	Unkown
HY-N9516A	Taurodehydrocholic acid sodium		99.87%	Unkown
HY-N9516	Taurodehydrocholic acid		/	Unkown
HY-RS00081	ABCG5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17755	Abcg5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24222	Abcg5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Abcg5	NCBI	NCBI:64240

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