2. Gene
  3. Irf5 - interferon regulatory factor 5 Gene

Irf5 - interferon regulatory factor 5 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as mirf5

Gene ID: 27056 | Gene type: protein coding

About Irf5

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and protein kinase binding activity. Involved in cytokine-mediated signaling pathway; defense response to Other organism; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in eye; ovary; telencephalon; and urinary system. Human ortholog(s) of this gene implicated in herpes simplex; inflammatory bowel disease 14; multiple sclerosis; rheumatoid arthritis; and systemic lupus erythematosus. Orthologous to human IRF5 (interferon regulatory factor 5). [provided by Alliance of Genome Resources, Apr 2022]

Irf5 Products(3)

mRNA Protein Name
NM_001252382.1 NP_001239311.1 interferon regulatory factor 5 isoform 1
NM_001311083.1 NP_001298012.1 interferon regulatory factor 5 isoform 3
NM_012057.4 NP_036187.1 interferon regulatory factor 5 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
15665823 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16236719 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
25326420 MGI
Biological Process GO Annotation Evidence Reference Source
involved in cytokine-mediated signaling pathway IDA
IDA: Inferred from direct assay
15665823 MGI
involved in defense response to virus IMP
IMP: Inferred from mutant phenotype
20451243 MGI
involved in innate immune response IDA
IDA: Inferred from direct assay
15665823 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15665823 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15665823 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15665823 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interferon regulatory factor 5

interferon regulatory factor 5 bone marrow

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-149652 IRF5-IN-1 Inhibitor 99.91% Unkown
HY-150095 YE6144 Inhibitor 96.47% Unkown
HY-P11003 PTD-N5-1 Inhibitor / Unkown
HY-P11072 IRF5-CPP5 Inhibitor / Unkown
HY-RS06909 IRF5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16837 Irf5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23279 Irf5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Irf5 NCBI NCBI:3663