Sptlc1 - serine palmitoyltransferase, long chain base subunit 1 Gene

Mus musculus

Also known as Lcb1; SPT1; E030036H05

Gene ID: 268656 | Gene type: protein coding

About Sptlc1

Summary

Enables serine C-palmitoyltransferase activity. Involved in regulation of fat cell apoptotic process and sphingomyelin biosynthetic process. Acts upstream of or within ceramide biosynthetic process; sphinganine biosynthetic process; and sphingosine biosynthetic process. Located in endoplasmic reticulum membrane. Is expressed in brain and liver. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 1A. Orthologous to human SPTLC1 (serine palmitoyltransferase long chain base subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Sptlc1 Products(1)

mRNA	Protein	Name
NM_009269.2	NP_033295.2	serine palmitoyltransferase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18484747	MGI
NOT enables serine C-palmitoyltransferase activity	IDA IDA: Inferred from direct assay	9363775	MGI
enables serine C-palmitoyltransferase activity	IMP IMP: Inferred from mutant phenotype	28100772	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within ceramide biosynthetic process	IMP IMP: Inferred from mutant phenotype	16216550	MGI
involved in regulation of fat cell apoptotic process	IMP IMP: Inferred from mutant phenotype	28100772	MGI
acts upstream of or within sphinganine biosynthetic process	IMP IMP: Inferred from mutant phenotype	19416652	MGI
involved in sphingolipid metabolic process	IMP IMP: Inferred from mutant phenotype	28100772	MGI
involved in sphingomyelin biosynthetic process	IDA IDA: Inferred from direct assay	26301690	MGI
acts upstream of or within sphingomyelin biosynthetic process	IMP IMP: Inferred from mutant phenotype	16216550	MGI
acts upstream of or within sphingosine biosynthetic process	IMP IMP: Inferred from mutant phenotype	16216550	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	26301690	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

serine palmitoyltransferase 1

long chain base biosynthesis protein 1

serine-palmitoyl-CoA transferase 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13736	SPTLC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21943	Sptlc1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sptlc1	NCBI	NCBI:10558

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