Cul3 - cullin 3 Gene

Mus musculus

Also known as KIAA0617

Gene ID: 26554 | Gene type: protein coding

About Cul3

Summary

Enables cyclin binding activity and identical protein binding activity. Involved in embryonic cleavage; integrin-mediated signaling pathway; and stem cell division. Acts upstream of or within with a positive effect on protein polyubiquitination. Acts upstream of or within several processes, including embryonic morphogenesis; fibroblast apoptotic process; and liver morphogenesis. Located in Golgi apparatus and nucleus. Is expressed in several structures, including extraembryonic component; gonad; heart; hemolymphoid system gland; and liver. Human ortholog(s) of this gene implicated in pseudohypoaldosteronism. Orthologous to human CUL3 (cullin 3). [provided by Alliance of Genome Resources, Apr 2022]

Cul3 Products(2)

mRNA	Protein	Name
NM_001313728.1	NP_001300657.1	cullin-3 isoform 2 precursor
NM_016716.5	NP_057925.1	cullin-3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cyclin binding	IPI IPI: Inferred from physical interaction	10500095	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	22709582	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	22709582	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Wnt signaling pathway	IDA IDA: Inferred from direct assay	19056892	MGI
acts upstream of or within cell morphogenesis	IMP IMP: Inferred from mutant phenotype	10500095	MGI
involved in embryonic cleavage	IMP IMP: Inferred from mutant phenotype	22358839	MGI
acts upstream of or within fibroblast apoptotic process	IMP IMP: Inferred from mutant phenotype	17339333	MGI
acts upstream of or within gastrulation	IMP IMP: Inferred from mutant phenotype	10500095	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	25250572	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	10500095	MGI
involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	25250572	MGI
involved in integrin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	22358839	MGI
acts upstream of or within liver morphogenesis	IMP IMP: Inferred from mutant phenotype	17339333	MGI
acts upstream of or within mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	17339333	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17339333	MGI
acts upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process	IGI IGI: Inferred from genetic interaction	20811152	MGI
involved in protein catabolic process	IMP IMP: Inferred from mutant phenotype	25250572	MGI
acts upstream of or within positive effect protein polyubiquitination	IDA IDA: Inferred from direct assay	27708159	MGI
involved in protein ubiquitination	IMP IMP: Inferred from mutant phenotype	25250572	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	24863065	MGI
involved in regulation protein catabolic process at postsynapse	IDA IDA: Inferred from direct assay	17062563	MGI
involved in regulation protein catabolic process at postsynapse	IEP IEP: Inferred from expression pattern	17062563	MGI
involved in regulation protein catabolic process at postsynapse	IMP IMP: Inferred from mutant phenotype	17062563	MGI
involved in stem cell division	IMP IMP: Inferred from mutant phenotype	22358839	MGI
acts upstream of or within trophectodermal cellular morphogenesis	IMP IMP: Inferred from mutant phenotype	10500095	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	10500095	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	24863065	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	17062563	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	17062563	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	17062563	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10500095	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cullin-3

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-126075A	WS-383	Inhibitor	99.88%	Unkown
HY-126075	WS-383 free base	Inhibitor	/	Unkown
HY-124834	Nrf2 activator-10		/	Unkown
HY-RS03361	CUL3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18472	Cul3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24953	Cul3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cul3	NCBI	NCBI:8452

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