2. Gene
  3. Map3k4 - mitogen-activated protein kinase kinase kinase 4 Gene

Map3k4 - mitogen-activated protein kinase kinase kinase 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Tas; MTK1; RP17; Mek4b; Mekk4; Rp17a; MEKK 4; D17Rp17; MAPKKK4; D17Rp17e; mKIAA0213

Gene ID: 26407 | Gene type: protein coding

About Map3k4

Summary

Enables protein kinase activity. Involved in intracellular signal transduction and positive regulation of JUN kinase activity. Acts upstream of or within several processes, including chorionic trophoblast cell differentiation; male germ-line sex determination; and placenta development. Located in cytoplasm. Is expressed in several structures, including central nervous system; future brain; and genitourinary system. Orthologous to human MAP3K4 (mitogen-activated protein kinase kinase kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

Map3k4 Products(2)

mRNA Protein Name
NM_001357722.1 NP_001344651.1 mitogen-activated protein kinase kinase kinase 4 isoform 2
NM_011948.2 NP_036078.2 mitogen-activated protein kinase kinase kinase 4 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12878610 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
16157600 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within chorionic trophoblast cell differentiation IMP
IMP: Inferred from mutant phenotype
19289495 MGI
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
16157600 MGI
acts upstream of or within male germ-line sex determination IMP
IMP: Inferred from mutant phenotype
6855886 MGI
acts upstream of or within placenta development IMP
IMP: Inferred from mutant phenotype
19289495 MGI
involved in positive regulation of JUN kinase activity IDA
IDA: Inferred from direct assay
16157600 MGI
acts upstream of or within positive regulation of JUN kinase activity IMP
IMP: Inferred from mutant phenotype
12878610 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
19289495 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16157600 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mitogen-activated protein kinase kinase kinase 4

MAPK/ERK kinase kinase 4

MEK kinase 4

T-associated sex reversal

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08057 MAP3K4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS19516 Map3k4 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS26011 Map3k4 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Map3k4 NCBI NCBI:4216